Comparison of human lung tissue mass measurements from ex vivo lungs and high resolution CT software analysis.

BMC Pulmonary Medicine
Erik HenneSteven Kesten

Abstract

Quantification of lung tissue via analysis of computed tomography (CT) scans is increasingly common for monitoring disease progression and for planning of therapeutic interventions. The current study evaluates the quantification of human lung tissue mass by software analysis of a CT to physical tissue mass measurements. Twenty-two ex vivo lungs were scanned by CT and analyzed by commercially available software. The lungs were then dissected into lobes and sublobar segments and weighed. Because sublobar boundaries are not visually apparent, a novel technique of defining sublobar segments in ex vivo tissue was developed. The tissue masses were then compared to measurements by the software analysis. Both emphysematous (n = 14) and non-emphysematous (n = 8) bilateral lungs were evaluated. Masses (Mean ± SD) as measured by dissection were 651 ± 171 g for en bloc lungs, 126 ± 60 g for lobar segments, and 46 ± 23 g for sublobar segments. Masses as measured by software analysis were 598 ± 159 g for en bloc lungs, 120 ± 58 g for lobar segments, and 45 ± 23 g for sublobar segments. Correlations between measurement methods was above 0.9 for each segmentation level. The Bland-Altman analysis found limits of agreement at the lung, lobe and ...Continue Reading

References

Aug 1, 1969·Journal of Applied Physiology·J C Hogg, S Nepszy
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·A DirksenJ Stolk
Mar 31, 2005·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jan-Martin KuhnigkTobias Achenbach
Dec 15, 2005·Proceedings of the American Thoracic Society·Juerg TschirrenMilan Sonka
Dec 16, 2005·IEEE Transactions on Medical Imaging·Juerg TschirrenMilan Sonka
Jan 10, 2006·IEEE Transactions on Medical Imaging·Li ZhangJoseph M Reinhardt
Feb 13, 2009·IEEE Transactions on Medical Imaging·Eva M van RikxoortBram van Ginneken
Nov 26, 2009·The Annals of Thoracic Surgery·Gregory I SnellTrevor J Williams
Jun 12, 2010·Therapeutic Advances in Respiratory Disease·Felix J F HerthArmin Ernst
Sep 24, 2010·The New England Journal of Medicine·Frank C SciurbaUNKNOWN VENT Study Research Group
Jan 14, 2011·Respiration; International Review of Thoracic Diseases·F J F HerthR Eberhardt

❮ Previous
Next ❯

Citations

Aug 13, 2015·Intensive Care Medicine Experimental·Alessandro ProttiLuciano Gattinoni
Jul 24, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S B HeymsfieldA Bosy-Westphal
May 4, 2016·Environmental Health Perspectives·Peggy S LaiDavid C Christiani
Feb 11, 2015·Journal of Medical Systems·Norliza M NoorJasjit S Suri
Dec 13, 2016·Academic Radiology·George R WashkoUNKNOWN COPDGene Investigators

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
dissections

Software Mentioned

VIDA
BTVA
Pulmonary Workstation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved