Comparison of human polymorphonuclear neutrophil elastase, polymorphonuclear neutrophil cathepsin-G, and alpha 2-macroglobulin levels in healthy and inflamed dental pulps

Journal of Endodontics
C R RauschenbergerE J Kaminski

Abstract

Polymorphonuclear neutrophils (PMNs) are found in dental pulp secondary to carious exposures, periodontal disease, or trauma. Lysosomal degranulation of these cells liberates cellular proteases, including elastase (PMN-E) and cathepsin-G (PMN-CG), which produce connective tissue degradation. However, nonspecific pulpal tissue destruction can be modified by a naturally occurring serum protease inhibitor alpha 2-macroglobulin (A2-M). This study relates the concentrations of human PMN-E, PMN-CG, and A2-M in healthy and inflamed pulpal samples. Evaluation of 21 specimens yielded statistically significant differences between healthy and moderate to severely inflamed pulps for all groups (p < 0.05). No significant correlation was detected among human PMN-E, PMN-CG, and A2-M in the healthy tissues (P > 0.05). However, in the moderate to severely inflamed pulps, there was a significant correlation between PMN-CG and A2-M (p < 0.05).

References

Jan 1, 1988·Archives of Oral Biology·I CondacciP Baehni

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Citations

Nov 17, 2009·Archives of Oral Biology·Masahito TsujiHiroshi Nakamura
May 16, 2008·International Endodontic Journal·M YamasakiH Nakamura
Mar 31, 2011·International Endodontic Journal·H MatsuiH Nakamura
Apr 1, 2014·Journal of Dentistry·Matthias ZehnderThomas Attin
May 8, 2015·The Journal of Clinical Pediatric Dentistry·E Emilia, P Neelakantan
Apr 1, 2003·European Journal of Oral Sciences·Heloisa GusmanMatthias Zehnder
Aug 23, 2008·Journal of Endodontics·Taisuke MorimotoHiroshi Nakamura

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