Comparison of human urine gastric inhibitor (HUGI) and bacterial endotoxin as inhibitors of acid secretion

European Journal of Pharmacology
M ImpicciatoreM I Grossman

Abstract

In conscious cats with gastric fistulas, 10 micrograms . kg-1 of human urinary gastric inhibitor (HUGI) given as an intravenous bolus injection increased mean rectal temperature 1.4 degree C and inhibited mean gastrin-stimulated acid secretion by 64%. The sample of HUGI contained an amount of beta-hydroxymyristic acid corresponding to a 5% contamination of the HUGI with bacterial endotoxin. Injection of bacterial endotoxin in an amount corresponding to the beta-hydroxymyritic acid content of HUGI mimicked, both in magnitude and time course, the increase in body temperature and the inhibition of acid secretion produced by HUGI. We conclude that inhibition of acid secretion by HUGI may be due to the presence of an endotoxin-like contaminant.

References

Jul 1, 1973·The Journal of Infectious Diseases·O LüderitzO Westphal
Jan 25, 1973·Biochimica Et Biophysica Acta·G CarreaG Lugaro
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S K MaitraL B Guze

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Citations

Jan 14, 1992·European Journal of Pharmacology·K TsujiM Namiki
Oct 29, 1993·Annals of the New York Academy of Sciences·A Uehara, M Namiki
Aug 1, 1987·British Medical Journal·S R Bloom, J M Polak
Jul 18, 1997·Biochemical and Biophysical Research Communications·C OotsuboY Kohgo

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