PMID: 7541310Nov 1, 1994Paper

Comparison of hydromorphone and meperidine for ureteral colic

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
N B JasaniJ K Bouzoukis

Abstract

To compare the efficacies of meperidine and hydromorphone in the treatment for ureteral colic in the emergency department (ED). A prospective, double-blind, randomized clinical trial was conducted over six months at a tertiary referral center with 93,000 annual ED visits. Seventy-three patients completed the study. The patients received either 1 mg of hydromorphone or 50 mg of meperidine IV at t = 0. Pain intensity was determined using a 10-cm visual analog scale at t = 0, 15, 30, 60, and 120 minutes. A second dose of the study drug could be given between t = 15 and t = 120 minutes when the clinician believed the initial dose was ineffective. Patients requiring more than one additional dose of analgesia were treated as nonresponders and were removed from the study. Thirty-six patients received hydromorphone and 37 received meperidine. The initial pain intensities (hydromorphone group = 8.4 +/- 1.5; meperidine group = 8.5 +/- 2.1), age distributions, sex distributions, and side effects of the two groups were comparable. Pain relief was better (p < 0.05) with hydromorphone at t = 15, 30, 60, and 120 minutes. The hydromorphone group required rescue analgesia less often (31% vs 68%, p < 0.01), had fewer IV pyelographies (IVPs) (28%...Continue Reading

References

Jul 1, 1978·British Journal of Clinical Pharmacology·C Maxwell
Jul 1, 1992·Radiology·M C HaddadA D Crawford
Apr 1, 1990·Journal of Pain and Symptom Management·L Cole, C D Hanning
Jan 25, 1986·British Medical Journal·J W Hetherington, N H Philp
Mar 15, 1988·Hospital Practice·F L Coe, J H Parks
Jan 1, 1983·European Journal of Clinical Pharmacology·H Quiding, S O Häggquist
Aug 1, 1983·Clinical Pharmacology and Therapeutics·K SriwatanakulG Mehta
May 1, 1993·British Journal of Urology·M GutmanJ M Baron
Aug 11, 1956·Journal of the American Medical Association·W H BOYCEH E STRAWCUTTER

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Citations

Oct 28, 2010·The Annals of Pharmacotherapy·Asad E PatanwalaBrian L Erstad
Feb 15, 2013·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Andrew K ChangE John Gallagher
Jan 10, 2002·American Journal of Therapeutics·Kenneth S LattaRobert L Barkin
Oct 29, 2013·The Cochrane Database of Systematic Reviews·Columba Quigley
Aug 29, 2018·Current Pain and Headache Reports·Ali PourmandMaryann Mazer-Amirshahi
Jun 20, 2018·Scandinavian Journal of Pain·Leila Niemi-MurolaKatri Hamunen
May 1, 1997·Emergency Medicine Clinics of North America·J J Martin, G P Moore
Apr 15, 2005·Emergency Medicine Clinics of North America·Grant D Innes, Peter J Zed

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