PMID: 9637622Jun 24, 1998Paper

Comparison of hydroxyapatite granules to autogenous bone graft in fusion cages in a goat model

Surgical Neurology
V MooneyR Holmes

Abstract

With the increased use of fusion cages to achieve lumbar intervertebral fusion, the question arises as to the potential for bone ingrowth from the host bone through the entire cage. Is it even necessary to have an autogenous graft to achieve total bone incorporation? Nine adult male goats had fusion cages implanted into three vertebral bodies. The design was Surgical Dynamics/Ray Fusion Cage, measuring 21 mm x 14 mm. In each animal, one fusion cage was filled with autogenous graft, one with hydroxyapatite, porous granules, and the other with nonporous granules. Amount of new bone formation was determined by backscatter electron microscopy at 3 months post implantation in all animals. The histologic section shows that there was total incorporation in all specimens at 3 months. There was slightly more new bone (43%) with the nonporous granules compared with the porous granules (35%). The amount of residual void space was about the same in all specimens, indicating that the amount of new bone formation was similar and not statistically different in cages filled with hydroxyapatite granules versus granules of autogenous bone. This study confirms that total incorporation by ingrowth of new bone can be expected in fusion cages. The a...Continue Reading

References

Jan 1, 1985·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K Shimazaki, V Mooney
Jan 1, 1988·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T ShimizuH K Hagler
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Nov 1, 1985·Journal of Neurosurgery·J M Otero Vich

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Citations

Sep 23, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Hao-Che ChuangDer-Yang Cho
May 25, 2012·Journal of Biomedical Materials Research. Part a·Tsai-Chin ShihNai-Chia Teng
Jul 14, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Rungnapa LowmunkongKunio Ishikawa
Jan 25, 2002·Clinical Orthopaedics and Related Research·Frank S KleinstueckDavid S Bradford
Feb 10, 2004·The Journal of Bone and Joint Surgery. British Volume·Y HattoriR Ohi

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