PMID: 8949759Jan 1, 1996Paper

Comparison of hyperfractionated conformal photon with conformal mixed neutron/photon irradiation in locally advanced prostate cancer

Bulletin du cancer. Radiothérapie : journal de la Société française du cancer : organe de la société française de radiothérapie oncologique
J D FormanC Orton

Abstract

In an attempt to improve the probability of complication-free local control for patients with locally advanced prostate cancer, a series of dose-finding studies have been conducted at Wayne State University using conformal neutron and hyperfractionated photon irradiation. In total, 96 patients with locally advanced prostate cancer (T3/T4 N0/N1 M0, and/or Gleason score > or = 8) were treated in two prospective studies. Forty-seven patients received conformal neutron/photon (15 NGy + 18 PhGy) and 49 patients were treated in a dose-escalation study using conformal photons (25 patients/78 Gy and 24 patients/83 Gy minimum dose). The median follow-up for both studies was 20 months (range 6-36 months). There was no significant difference in the rate of chronic gastrointestinal (GI) or gastrourinary (GU) morbidity between the two groups. However, the neutron treated patients had a significantly higher rate of moderate (14%) and severe (12%) hip stiffness. The rates of prostate-specific antigen (PSA) decline and 12-month negative biopsy were comparable. In conclusion, the therapeutic gain of neo-adjuvant hormonal therapy in combination with photon hyperfractionation to 83 Gy appears identical to that seen with the mixed neutron-photon d...Continue Reading

References

Sep 1, 1985·International Journal of Radiation Oncology, Biology, Physics·G E LaramoreF R Hendrickson
Jun 15, 1995·International Journal of Radiation Oncology, Biology, Physics·T E SchultheissW R Lee

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Citations

Jun 30, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Deepak KhuntiaMinesh P Mehta
Apr 29, 1998·Seminars in Radiation Oncology·C J RossiJ M Slater
Aug 7, 2007·International Journal of Radiation Oncology, Biology, Physics·Lakshmi SantanamJay Burmeister

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