PMID: 8937798Nov 1, 1996Paper

Comparison of hyperinsulinaemic clamp experiments using venous, 'arterialized' venous or capillary euglycaemia

Clinical Physiology
M A NauckC Qualmann

Abstract

It has been suggested that deviations from arterial euglycaemia during hyperinsulinaemic clamp experiments that use venous plasma glucose measurements may alter the results of such tests (glucose infusion rate, C-peptide suppression, etc.) and that 'arterialized' venous blood ('heated-hand' technique) may be suitable to circumvent these problems. Therefore, nine normal male fasting volunteers (age 25 +/- 4 years, body mass index 23.5 +/- 2.3 kg m-2) were examined three times using an insulin infusion of 1 mU kg min-1 over 120 min. Glucose was infused to maintain a concentration of 4.7 mmol I-1 (85 mg dl-1) in venous (V), 'arterialized' venous ('heated-hand' technique; HH), or capillary (C) plasma. The 'heated-hand' technique caused a rise in (rectal) body temperature of 0.3 +/- 0.1 degree C (P < 0.0001). Whereas the glucose aim was reached to a similar degree in all experiments (P = 0.36), capillary glucose concentrations differed slightly, but significantly (higher in experiments with venous and 'arterialized' venous blood specimens; P = 0.034). There were no significant differences regarding steady-state insulin concentrations (P = 0.77), glucose infusion rates (V, 7.1 +/- 0.5; HH, 7.2 +/- 0.6; C, 6.4 +/- 0.5 mg kg-1 min-1; P...Continue Reading

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Citations

Mar 26, 2011·Diabetes & Metabolism·B Antuna-PuenteJ-P Bastard
May 27, 2008·Metabolism: Clinical and Experimental·Walid KaplanMorey W Haymond
Apr 30, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·K J NewensC M Williams
Jun 22, 2016·Diabetes, Obesity & Metabolism·Tim HeiseThomas Forst
Oct 20, 2009·The Journal of Clinical Endocrinology and Metabolism·Kristine J HareTina Vilsbøll

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