Comparison of hypertonic vs isotonic fluids during resuscitation of severely burned patients

The American Journal of Emergency Medicine
Monika Kristaq BelbaGjergji Petro Belba

Abstract

The hypertonic lactate saline (HLS) solutions with mild concentration of sodium have been used in some burn centers to maintain plasma volume without infusing larger fluids volumes. To evaluate the fluid requirements during resuscitation with lactated Ringer's solution and to realize resuscitation with HLS, we suggest the following clinical trial. Specific objectives include fluid loads, sodium loads, and fluid accumulation. This prospective study included 110 patients with severe burns. The first group included patients resuscitated in the beginning with lactated Ringer's solution, according to Parkland formula for adults and Shriner formula for children. In the other group, the patients were resuscitated with HLS solution. Patients are divided in 2 groups for comparison. There is difference between sodium loads (P = .03), fluid load in the first hour (P = .001), sodium load in the first hour (P = .001), and net fluid accumulation (P = .0025). There is a difference regarding plasma sodium and plasma osmolality in the first hour (P = .003, P = .002). There is difference regarding sodium given (P = .001) and sodium excreted (P = .001) in 2 groups. Hypertonic resuscitation consists in giving a higher fluid and sodium load in the ...Continue Reading

References

Dec 1, 1986·American Journal of Surgery·S W MerrellG D Warden
Jan 1, 1985·The Journal of Trauma·B H Bowser-WallaceF T Caldwell
Jul 27, 2002·The Journal of Burn Care & Rehabilitation·Robert C CartottoAndrew B Cooper
Nov 24, 2004·Burns : Journal of the International Society for Burn Injuries·C HolmU J Pfeiffer
Nov 9, 2005·Burns : Journal of the International Society for Burn Injuries·L-P KamolzM Frey
Aug 10, 2007·ANZ Journal of Surgery·Csaba CsontosLajos Bogar

❮ Previous
Next ❯

Citations

Mar 7, 2012·International Journal of Clinical Pharmacy·Maryam MousaviSimin Dashti-Khavidaki
Nov 15, 2011·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Frederick W Endorf, David J Dries
Feb 14, 2016·Medicina intensiva·M Sánchez-SánchezM J Asensio
Aug 16, 2014·Critical Care : the Official Journal of the Critical Care Forum·Thibault DuburcqMercé Jourdain
Jan 29, 2013·Anesthesiology Clinics·Samuel M Galvagno, Colin F Mackenzie
Feb 13, 2015·Critical Care : the Official Journal of the Critical Care Forum·Eric FontaineCarole Ichai
Sep 17, 2013·Lancet·Marc G Jeschke, David N Herndon
Jun 9, 2016·Burns : Journal of the International Society for Burn Injuries·Alice HenschkeAnthony Delaney
Jan 8, 2013·Journal of Burn Care & Research : Official Publication of the American Burn Association·Katrina B MitchellJames J Gallagher
Oct 13, 2017·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Yuan KaoKa-Wai Tam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

JAMA : the Journal of the American Medical Association
Aryeh ShanderGary Thompson
Journal of Burn Care & Research : Official Publication of the American Burn Association
J R Saffle
Journal of Burn Care & Research : Official Publication of the American Burn Association
Amanda LawrenceJ R Saffle
Burns : Journal of the International Society for Burn Injuries
David G Greenhalgh
Journal of Burn Care & Research : Official Publication of the American Burn Association
Iris FaraklasJ R Saffle
© 2022 Meta ULC. All rights reserved