Comparison of hypotensive, diuretic and renal effects between cladodes of Opuntia ficus-indica and furosemide

Asian Pacific Journal of Tropical Medicine
Meryem BakourBadiaâ Lyoussi

Abstract

To investigate the diuretic, hypotensive and renal effect of Opuntia ficus-indica in two different species in oral and intravenous administration. Diuretic activity was evaluated in rats with the plant cladode gel and aqueous extract administrated orally, and was evaluated in rabbits with plant extract administered intravenously. Single and repeated doses of cladode gel or aqueous extract of cladode were tested. Urine volume and blood and urine creatinine, sodium and potassium were measured, and creatinine clearance was calculated. The hypotensive effect of lyophilized extract of cladode was evaluated in rabbits. Two polyethylene PE50 catheters were used: one in the jugular vein for the infusion of the plant extract and the other in the carotid for the evaluation of the arterial pressure. The cladode gel or aqueous extract increased urine volume, creatinine clearance and urinary excretion of sodium and potassium without significant effect on serum creatinine or blood urea. Furosemide, gel and aqueous extract of cladode insignificantly lowered plasma potassium in rats. Intravenous administration of the lyophilized extract caused a significant decrease in mean arterial pressure in rabbits with a significant increase in urine volu...Continue Reading

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Citations

May 8, 2020·Biological & Pharmaceutical Bulletin·Mehmet Evren Okurİsmail Seçkin
Jan 29, 2021·TheScientificWorldJournal·Meryem BakourBadiaa Lyoussi
Aug 31, 2019·Food Research International·Juliana Gondim de AlbuquerquePatrícia Moreira Azoubel

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