PMID: 18203069Jan 19, 2008Paper

Comparison of icodextrin- and glucose-based peritoneal dialysis fluids in their acute and chronic effects on human peritoneal mesothelial cells

The International Journal of Artificial Organs
Thorsten O BenderAchim Jörres

Abstract

Icodextrin-based peritoneal dialysis fluids (PDFs) display several features that may potentially improve their biocompatibility compared to conventional glucose-containing solutions. So far, however, the studies assessing the biocompatibility profile of icodextrin toward human peritoneal mesothelial cells (HPMC) has produced mixed results. The present study was performed to examine the acute and chronic impact of icodextrin on HPMC in vitro in comparison with standard glucose-based PDF. Omentum-derived HPMC were either acutely pre-exposed to or incubated chronically (for up to 10 days) in the presence of icodextrin-PDF. Parallel cultures were treated with conventional PDFs containing either 1.5% or 4.25% glucose. All fluids were tested at neutral pH. HPMC were assessed for viability, proliferation, IL-6 secretion and generation of reactive oxygen species (ROS). Incubation in the presence of icodextrin-PDF significantly reduced HPMC proliferation in a manner similar to that of 1.5% glucose-PDF. In addition, exposure to icodextrin-PDF impaired viability and IL-6 release from HPMC. This effect occurred both after the short pre-treatment with neat icodextrin-PDF for 1-4 hours and after prolonged incubation (up to 10 days) in media ...Continue Reading

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Citations

Feb 4, 2012·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Sylvie OpatrnaNicholas Topley
Oct 9, 2014·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Keiichi WakabayashiYasuhiko Tomino
May 11, 2012·Journal of Materials Science. Materials in Medicine·Christoph BrochhausenC James Kirkpatrick
Jan 26, 2013·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Asher A MendelsonCaigan Du

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