PMID: 11330620May 2, 2001Paper

Comparison of immediate intradermal test reactivity with serum IgE quantitation by use of a radioallergosorbent test and two ELISA in horses with and without atopy

Journal of the American Veterinary Medical Association
G LorchB E LeRoy

Abstract

To compare a radioallergosorbent test and 2 ELISA with intradermal testing for the determination of environmental allergen hypersensitivity in horses with and without atopic diseases. Prospective clinical study. 10 horses with recurrent urticaria, 7 with atopic dermatitis, 16 with chronic obstructive pulmonary disease, and 22 without atopy. History, physical examination, hemogram, serum biochemical analyses, bronchoalveolar lavage, and an intradermal test (used as the criterion standard) with a regional panel of 73 allergens were performed in all horses. Serum was analyzed by use of the 3 in vitro assays of allergen-specific IgE. An ELISA based on the alpha chain of the high-affinity IgE receptor, the Fcepsilon receptor immunoglobin epsilon chain (FcepsilonRIalpha) for IgE, had the overall highest kappa statistic (0.238), positive predictive value (49%), and negative predictive value (78%). Overall agreement between the FcepsilonRIalpha-based ELISA and the intradermal test was fair. The highest kappa statistic was obtained by the FcepsilonRIalpha-based ELISA in horses with atopic dermatitis (0.330). Kappa statistics for the radioallergosorbent test and a polyclonal antibody-based ELISA agreed slightly with that of the intraderm...Continue Reading

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Citations

Feb 24, 2007·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Laurie J GageStephen D White
Jul 23, 2014·Research in Veterinary Science·R MarsellaK Ahrens
Oct 12, 2013·Journal of Veterinary Internal Medicine·G LorchK K Isler
Nov 26, 2013·The Veterinary Clinics of North America. Equine Practice·Valerie A Fadok
Nov 26, 2013·The Veterinary Clinics of North America. Equine Practice·Rosanna Marsella
Oct 13, 2009·Veterinary Immunology and Immunopathology·Bettina Wagner
Nov 26, 2008·Veterinary Immunology and Immunopathology·L TahonE Marti
Dec 25, 2007·Veterinary Immunology and Immunopathology·Kathrin F A LangnerWolfgang Leibold
Aug 4, 2020·Veterinary Dermatology·Catharina M M van DammeMarianne M Sloet van Oldruitenborgh-Oosterbaan
Nov 29, 2002·Equine Veterinary Journal·C LebisF Marzin-Keller
Oct 24, 2017·Veterinary Sciences·Rosanna Marsella, Anna De Benedetto

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