PMID: 6966182Apr 15, 1980Paper

Comparison of immune derangements in patients with different malignancies

Cancer
A LichtensteinJ L Fahey

Abstract

Immune function was evaluated in 109 patients with carcinoma of the breast, bladder, head and neck, and lung. Patients with head and neck cancer showed the most profound derangements of immune function; patients with lung cancer showed no detectable abnormalities. Non-irradiated patients with disseminated head and neck cancer had significantly depressed lymphocyte counts (mean 1357/mm3, P less than .05), E-rosette forming cells (mean 770/mm3, P less than .05), and response to phytohemagglutinin (P less than .05) as compared to controls. This immunodeficiency was detected in patients with localized as well as advanced disease. Although significant differences were noted between patients with head and neck cancer and the other tumors, these differences were minimized by radiation therapy. All irradiated patients showed comparable degrees of immune dysfunction. Absolute Fc-receptor cells were depressed in all irradiated patients and in non-irradiated patients with disseminated breast cancer.

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Citations

Jul 1, 1983·Journal of Clinical Immunology·J L Murray, G M Kollmorgen
Feb 1, 1982·Oral Surgery, Oral Medicine, and Oral Pathology·C Scully
Apr 1, 1993·European Journal of Cancer. Part B, Oral Oncology·N Yamanaka
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Jan 20, 2009·International Journal of Environmental Research and Public Health·Sunali Khanna
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May 1, 1993·Journal of the American Academy of Dermatology·G CarteiE Vigevani
Jul 1, 1989·The Korean Journal of Internal Medicine·J O Kim, S Y Kim
Nov 5, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M N FaleweeM Ettaiche
Jun 1, 1983·The British Journal of Oral Surgery·C Scully
Apr 17, 1999·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M A van Bokhorst-De van der SchuerP A van Leeuwen
Jan 1, 1990·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·S J Gerson
Aug 1, 1996·Hematology/oncology Clinics of North America·C Emmanouilides, J Glaspy
Aug 1, 1996·Hematology/oncology Clinics of North America·D Y Kavanaugh, D P Carbone
Jan 1, 1987·Medical Oncology and Tumor Pharmacotherapy·P Lozac'hP Youinou

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