Comparison of immunoadjuvant activities of four bursal peptides combined with H9N2 avian influenza virus vaccine

Journal of Veterinary Science
Cong ZhangChen Wang

Abstract

The bursa of Fabricius (BF) is a central humoral immune organ unique to birds. Four bursal peptides (BP-I, BP-II, BP-III, and BP-IV) have been isolated and identified from the BF. In this study, the immunoadjuvant activities of BPs I to IV were examined in mice immunized with H9N2 avian influenza virus (AIV) vaccine. The results suggested that BP-I effectively enhanced cell-mediated immune responses, increased the secretion of Th1 (interferon gamma)- and Th2 (interleukin-4)-type cytokines, and induced an improved cytotoxic T-lymphocyte (CTL) response to the H9N2 virus. BP-II mainly elevated specific antibody production, especially neutralizing antibodies, and increased Th1- and Th2-type cytokine secretion. BP-III had no significant effect on antibody production or cell-mediated immune responses compared to those in the control group. A strong immune response at both the humoral and cellular levels was induced by BP-IV. Furthermore, a virus challenge experiment followed by H&E staining revealed that BP-I and BP-II promoted removal of the virus and conferred protection in mouse lungs. BP-IV significantly reduced viral titers and histopathological changes and contributed to protection against H9N2 AIV challenge in mouse lungs. Thi...Continue Reading

References

Jul 23, 1976·Science·A BrandG Goldstein
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J W YewdellB Moss
Feb 1, 1997·Vaccine·J C Cox, A R Coulter
Jun 5, 1998·Veterinary Immunology and Immunopathology·M LeenaarsE Claassen
Apr 20, 2000·The Journal of Clinical Investigation·J L Ferrara
Dec 5, 2000·Current Opinion in Immunology·M G Roncarolo, M K Levings
Oct 14, 2004·Immunology and Cell Biology·Nikolai Petrovsky, Julio César Aguilar
Jan 15, 2008·Veterinary Immunology and Immunopathology·Chen WangPu-Yan Chen
Dec 21, 2011·The Journal of Biological Chemistry·Xiu-Li FengPu-Yan Chen
Mar 15, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·De-yuan LiPu-yan Chen
Aug 30, 2014·Amino Acids·Xiao-Dong LiuPu-Yan Chen

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
Assay
PCR

Software Mentioned

GraphPad Prism
GraphPad

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.