Abstract
The subsets and the polarization of lymphocytes in bone marrow from low-risk myelodysplastic syndrome (MDS) were studied and compared with those from patients with aplastic anemia (AA). A total of 34 patients with low-risk MDS (IPSS score< or =1.0) who presented abnormal chromosomes and 16 patients with AA were enrolled in this study. We determined T lymphocyte subsets, T cells polarization status, and the percentages of NK cells and of B lymphocytes in bone marrow and compared these parameters between the two groups of patients. As controls, 24 patients with high-risk MDS (IPSS score>1.0) presenting abnormal chromosomes and 22 healthy/benign hematologic disease subjects were used. In low-risk MDS/AA patients, the percentage of CD3+ lymphocytes was significantly increased compared to controls (p=0.006 and p=0.001), while the percentage of CD19+ lymphocytes was significantly decreased (p<0.001 and p=0.002); there were no significant differences between MDS/AA and normal controls in other parameters; For low-risk MDS patients, the polarization status of bone marrow CD4+ cells toward Th1 (Th1/Th2) and of CD8+ cells toward Tc1 (Tc1/Tc2) was stronger than that for AA patients (p=0.05 and p<0.001). Other parameters did not show signi...Continue Reading
References
Feb 1, 1983·British Journal of Haematology·E C Gordon-Smith
Feb 26, 1993·Journal of Immunological Methods·T JungC Rieger
Nov 30, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N L HarrisC D Bloomfield
Jul 27, 2000·American Journal of Hematology·H Tsuda, H Yamasaki
Oct 31, 2001·Leukemia Research·D E EppersonA J Barrett
Apr 20, 2002·Blood·Jaroslaw P MaciejewskiNeal S Young
Oct 3, 2002·British Journal of Haematology·J Joseph MelenhorstA John Barrett
Nov 2, 2002·Blood·David P SteensmaAyalew Tefferi
Nov 15, 2002·International Journal of Hematology·Jaroslaw P MaciejewskiNeal S Young
Dec 17, 2002·Experimental Hematology·Irith BaumannNydia G Testa
Apr 2, 2003·Blood Cells, Molecules & Diseases·Margarida LimaBenvindo Justiça
Apr 4, 2003·Blood·Marcus HarbordHannah Mitchison
Aug 30, 2003·Blood·Naoto HiranoLee M Nadler
Nov 25, 2003·British Journal of Haematology·J C W MarshUNKNOWN British Committee for Standards in Haematology
Jun 26, 2004·Blood·Xingmin FengShinji Nakao
Aug 4, 2005·Blood·Alexander SternbergParesh Vyas
Jan 27, 2006·Leukemia·W H MatsuiR J Jones
Apr 1, 2006·Blood·Kiyoyuki OgataAkio Hayashi
Jun 17, 2006·Blood·Neal S YoungPhillip Scheinberg
May 18, 2007·Leukemia·Z Y LimG J Mufti
Dec 3, 2008·International Journal of Laboratory Hematology·L WuQ Pu
Apr 2, 2009·Haematologica·A John Barrett, Elaine Sloand
Citations
Feb 5, 2013·Experimental Hematology·Li LiuSiobán Keel
Jan 22, 2013·European Journal of Haematology·Zheng ZhangChunkang Chang
Oct 3, 2015·Leukemia Research·Jun WuLeping Zhang
Apr 2, 2013·Hematology·Shucheng GuXiao Li
Jun 8, 2015·Medical Oncology·Feng ZhuKai-lin Xu
Nov 28, 2019·Journal of Oncology·Zhi-Qin LiuYang-Zhe Wu
Aug 25, 2018·Cancer Discovery·Yoshihiro HayashiGang Huang
Jan 7, 2021·Cancers·Bruno FattizzoChiara Caprioli
Feb 3, 2021·Cell Transplantation·Liu FangZhu Xiaofan
Sep 25, 2017·Life Sciences·Hai-Fang ZhangZhi-Feng Yu
Aug 19, 2021·Best Practice & Research. Clinical Haematology·Theodoros Karantanos, Amy E DeZern