Comparison of Immunological Characteristics of Mesenchymal Stem Cells from the Periodontal Ligament, Umbilical Cord, and Adipose Tissue

Stem Cells International
Jin-Hee KimYoung-Il Hwang

Abstract

Mesenchymal stem cells (MSCs) are of therapeutic importance in the fields of regenerative medicine and immunological diseases. Accordingly, studies evaluating MSCs for clinical applications are increasing. In this study, we characterized MSCs from the periodontal ligament, umbilical cord (UC-MSCs), and adipose tissue, which were relatively easy to obtain with limited ethical concerns regarding their acquisition, and compared their immunological characteristics. Among MSCs isolated from the three different tissues, UC-MSCs grew the fastest in vitro. The three types of MSCs were shown to inhibit proliferation of activated peripheral blood mononuclear cells (PBMCs) to a similar degree, via the indoleamine 2,3-dioxygenase and cyclooxygenase-2 pathways. They were also shown to inhibit the proliferation of PBMCs using HLA-G, which was most prominent in UC-MSCs. Unlike the other two types of MSCs, UC-MSCs showed minimal expression of HLA-DR after activation, suggesting that they pose minimal risk of initiating an allogeneic immune response when administered in vivo. These characteristics, the ease of collection, and the minimal ethical concerns regarding their use suggest UC-MSCs to be suitable MSC therapeutic candidates.

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Citations

Apr 25, 2019·Stem Cells and Development·Oriana TrubianiFrancesca Diomede
Jan 26, 2020·Journal of Periodontology·Daneeya ChaikeawkaewPrasit Pavasant
Feb 24, 2020·Stem Cell Reviews and Reports·Bernardo ZoehlerMaria Da Graça Bicalho
Jul 30, 2020·Stem Cells International·Mengyuan WangHongzhi Fang
May 14, 2020·World Journal of Stem Cells·Christine BojanicWasim S Khan
Jun 13, 2020·International Journal of Molecular Sciences·Carina da SilvaMichael S Pepper
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Nov 15, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Mehdi NajarHassan Fahmi
Jul 13, 2021·World Journal of Stem Cells·Aline QueirozMarinella Holzhausen

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Methods Mentioned

BETA
Polymerase Chain Reaction
PCR
electrophoresis
flow cytometry
ELISA

Software Mentioned

Quantity One
GraphPad Prism
SPSS

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