Comparison of immunological effects of Fullerene C60 and raw soot from Fullerene production on alveolar macrophages and macrophage like cells in vitro

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
T BaierlS Hippeli

Abstract

Two carbon modifications, C60 and Raw Soot (RS) from fullerene production, were incubated with macrophages and macrophage-like cells. Their effects were compared both to DQ12 Quartz as a positive particle control known to damage BAM and HL60M, and LPS or zymosan as biological inducers of immunological reactions. C60 as well as RS are not cytotoxic as compared to DQ12. C60 seems to induce a lower chemotactic activity than RS and DQ12. Furthermore, C60 is of no or only very little influence on the formation of reactive oxygen species (ROS). RS itself is oxidatively active both with H2DFC-DA in in vitro cell culture and with KMB in a cell free incubation under the influence of light. It is not yet clear whether the in vitro effects of RS are caused by ROS formation by the cells and/or the oxidative activity due to light as indicated from the results with KMB.

References

Jun 1, 1991·Journal of Toxicology and Environmental Health·J Schimmelpfeng, A Seidel

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Citations

Apr 9, 2002·Bioorganic & Medicinal Chemistry·Kelly A GonzalezGeorge H Nancollas
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·D W CagleL J Wilson
Oct 9, 2008·Nihon eiseigaku zasshi. Japanese journal of hygiene·Akihiko Hirose, Seishiro Hirano
Dec 5, 1998·Chemico-biological Interactions·J P KamatJ P Mittal
Jun 19, 2017·Biochemical and Biophysical Research Communications·Yosuke TabeiMasanori Horie
May 13, 2009·Nanotechnology·Fang LaoChunying Chen
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mona JaniMing Ni
Apr 30, 2008·Environmental Science & Technology·Dang Sheng SuSilvana Fiorito
Aug 10, 2021·Frontiers in Cell and Developmental Biology·Rituraj NiranjanAshwani Kumar Thakur

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