Comparison of in vitro activities and pharmacokinetics/pharmacodynamics estimations of veterinary fluoroquinolones against avian pathogenic Escherichia coli isolates

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Manao OzawaTetsuo Asai

Abstract

We analyzed in vitro activities and pharmacokinetics/pharmacodynamics (PK/PD) parameters of veterinary fluoroquinolones against avian pathogenic Escherichia coli (APEC) strains from cases of avian colibacillosis. The median of minimum inhibitory concentration (MIC(50)) values against APEC strains for enrofloxacin (ERFX) and danofloxacin (DNFX) were 0.25 μg/ml and for norfloxacin (NFLX) and ofloxacin (OFLX) were 0.5 μg/ml. The percentage of resistant strains for ERFX, DNFX, NFLX, and OFLX were 24.4%, 23.6%, 22.8%, and 23.6%, respectively. Scattergrams of the MICs of ERFX compared to DNFX, NFLX, and OFLX for 127 strains demonstrate a clear correlation between the MIC of ERFX and that of other fluoroquinolones. The differences in amino acid substitution in GyrA may play a role in the variation of MIC values for fluoroquinolones. The ratios of peak serum concentration to MIC (C(max):MIC) and ratios of area under the curve to MIC (AUC:MIC) were relatively high in ERFX and OFLX compared to other fluoroquinolones. These results indicate that although the in vitro activities of these fluoroquinolones against APEC isolates are slightly different, the PK/PD values vary with PK parameters. Therefore, we need to consider the PK/PD paramete...Continue Reading

References

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Citations

Jul 12, 2012·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Allison N WackMary Denver
Jan 19, 2016·Frontiers in Veterinary Science·KaNa SangZongHui Yuan
Jan 3, 2012·Environmental Toxicology and Pharmacology·Starling KalpanaJitendra K Malik
May 6, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Shubhangi ShirsatKwang Ho Kim
Jun 24, 2021·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Manao OzawaMayumi Kijima

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Methods Mentioned

BETA
PCR

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