Comparison of in vitro activities of eight beta-lactamase-stable cephalosporins against beta-lactamase-producing gram-negative bacilli.

Antimicrobial Agents and Chemotherapy
L Verbist

Abstract

In vitro activities of eight beta-lactamase-stable cephalosporins, cefoxitin, cefuroxime, cefotaxime, moxalactam, SCE-1365, cefoperazone, ceftazidime, and cefsulodin, were compared against selected cephalothin-resistant or beta-lactamase-producing gram-negative bacilli or both. SCE-1365, cefotaxime, moxalactam, and ceftazidime had very similar activities against Enterobacteriaceae; SCE-1365 displayed the highest activity, and ceftazidime displayed the lowest activity. These four antibiotics were about 20 times more active than cefoperazone and 50 to 100 times more active than cefoxitin and cefuroxime. Against Pseudomonas aeruginosa and the other Pseudomonas species, ceftazidime showed the highest activity by far, followed by cefsulodin and cefoperazone. A close parallel resistance against P. aeruginosa isolates was observed between piperacillin on the one hand and cefoperazone and cefsulodin on the other.

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Citations

Jun 1, 1982·European Journal of Clinical Microbiology·P C AppelbaumG A Pankuch
Jun 1, 1982·Antimicrobial Agents and Chemotherapy·H L Muytjens, J van der Ros-van de Repe
Aug 1, 1982·Antimicrobial Agents and Chemotherapy·T B TjandramagaL Verbist
Nov 1, 1983·Antimicrobial Agents and Chemotherapy·J S LeederS M MacLeod
May 1, 1985·Antimicrobial Agents and Chemotherapy·M J HornsteinP A Grimont
Jul 1, 1985·Antimicrobial Agents and Chemotherapy·J C EngleC J Schleupner
Apr 1, 1987·Antimicrobial Agents and Chemotherapy·M R ScavizziA Guiyoule
Jul 1, 1982·Antimicrobial Agents and Chemotherapy·R K ScribnerC H Pai
Feb 25, 1988·The New England Journal of Medicine·G R Donowitz, G L Mandell
May 1, 1984·The American Journal of Medicine·F W KahnW A Agger
Sep 1, 1983·Drug Intelligence & Clinical Pharmacy·P GarzoneV L Yu
Jan 1, 1983·Drug Intelligence & Clinical Pharmacy·J A Lyon
Dec 1, 1984·Drug Intelligence & Clinical Pharmacy·R E PolkP Patterson
Feb 1, 1982·Drug Intelligence & Clinical Pharmacy·R E Polk
Sep 1, 1984·Drug Intelligence & Clinical Pharmacy·M D ReedJ L Blumer

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