Abstract
Caspofungin activity was determined in vitro and in vivo against three Candida orthopsilosis, three C. metapsilosis, two C. parapsilosis sensu stricto and two C. albicans isolates. MIC values and killing activity were determined in RPMI-1640 plus 50 % human serum. Neutropenic (cyclophosphamide-treated) mice were infected intravenously. Five-day intraperitoneal treatment with caspofungin was started after 24 h postinfection. Kidney burden was analyzed using the Kruskal-Wallis test with Dunn's post-test. In killing studies, caspofungin was fungistatic and fungicidal against C. albicans at ≥0.25 and ≥2 μg/ml concentrations, respectively. Caspofungin was fungistatic at ≥8-16, ≥2-8 and at ≥2-8 μg/ml against C. parapsilosis, C. orthopsilosis and C. metapsilosis, respectively. In the murine model, C. albicans was inhibited by 1, 2 and 5 mg/kg of caspofungin (P < 0.001 compared to the controls). Against C. parapsilosis, only 5 mg/kg caspofungin was effective against both isolates (P < 0.05). Two and five mg/kg of caspofungin was effective against all C. orthopsilosis and C. metapsilosis isolates (P < 0.05 to <0.001). Serum-based killing tests proved to be useful in predicting in vivo efficacy of caspofungin agai...Continue Reading
References
Feb 19, 2002·Antimicrobial Agents and Chemotherapy·Julie A StoneScott A Waldman
Mar 26, 2003·Antimicrobial Agents and Chemotherapy·D AndesR Conklin
Jan 7, 2005·Journal of Clinical Microbiology·Arianna TavantiFrank C Odds
Jul 28, 2006·Antimicrobial Agents and Chemotherapy·Francesco BarchiesiGiorgio Scalise
Jan 16, 2007·Clinical Microbiology Reviews·M A Pfaller, D J Diekema
Apr 11, 2007·Antimicrobial Agents and Chemotherapy·Padmaja PaderuDavid S Perlin
Sep 6, 2007·Antimicrobial Agents and Chemotherapy·Zekaver OdabasiLuis Ostrosky-Zeichner
Feb 21, 2008·Antimicrobial Agents and Chemotherapy·A Gomez-LopezUNKNOWN Barcelona Candidemia Project Study Group
Apr 2, 2008·Haematologica·Nabil KabbaraPatricia Ribaud
Apr 30, 2008·Antimicrobial Agents and Chemotherapy·Guillermo Garcia-EffronDavid S Perlin
Jun 17, 2008·Diagnostic Microbiology and Infectious Disease·Eveline van AsbeckDavid A Stevens
Jun 20, 2008·Journal of Clinical Microbiology·Shawn R LockhartDaniel J Diekema
Oct 1, 2008·The Journal of Antimicrobial Chemotherapy·I VargaL Majoros
Feb 5, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasUNKNOWN Infectious Diseases Society of America
Apr 28, 2009·Diagnostic Microbiology and Infectious Disease·Zsuzsa SzabóLászló Majoros
May 8, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert F BettsUNKNOWN Caspofungin High-Dose Study Group
Aug 19, 2009·Antimicrobial Agents and Chemotherapy·Jun IshikawaYuzuru Kanakura
Feb 11, 2010·Antimicrobial Agents and Chemotherapy·Emilia CantónLucas del Castillo
Aug 4, 2010·Journal of Clinical Pharmacology·Elizabeth M MigoyaJohn A Wagner
Mar 1, 2011·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·M A PfallerUNKNOWN CLSI Subcommittee for Antifungal Testing
Mar 9, 2011·Antimicrobial Agents and Chemotherapy·Guillermo Garcia-EffronDavid S Perlin
Apr 27, 2011·Antimicrobial Agents and Chemotherapy·Amy M FlatteryGeorge K Abruzzo
May 17, 2011·Journal of Chemotherapy·S BayeganL Majoros
May 2, 2012·Journal of Chemotherapy·Judit SzilágyiLászló Majoros
Citations
Nov 2, 2018·Mycopathologia·Zoltán TóthLászló Majoros
Mar 19, 2014·Acta Microbiologica Et Immunologica Hungarica·Renátó KovácsJózsef Kónya
Jul 22, 2018·Journal of Chemotherapy·Tamás KardosLászló Majoros
Aug 25, 2015·Journal of Medical Microbiology·Marianna DománLászló Majoros
Nov 5, 2013·Journal of Medical Microbiology·Renátó KovácsLászló Majoros
Jan 27, 2016·Mycoses·Sarah Santos GonçalvesArnaldo Lopes Colombo
Jul 13, 2017·Mycopathologia·Renátó KovácsLászló Majoros
Aug 28, 2015·Revista Da Sociedade Brasileira De Medicina Tropical·Fábio Silvestre AtaidesMaria do Rosário Rodrigues Silva
Apr 11, 2013·Expert Review of Pharmacoeconomics & Outcomes Research·Stuart J TurnerDavid C M Kong
Jan 11, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Qasem SalehLászló Majoros
Feb 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Miklós NagySándor Kéki
Aug 15, 2014·Mycopathologia·Renátó KovácsLászló Majoros