Comparison of in vitro biocompatibility of silicone and polymethyl methacrylate during the curing phase of polymerization

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Wei SongWeiping Ren

Abstract

Adverse events have been reported with acrylic bone cements. However, current test standards for acrylic materials fail to characterize the potentially harmful monomers released during the curing stage. In clinical applications, materials are implanted into the human body during this phase. Silicone may be a safer alternative to acrylic cements. Silicone is used in medical applications for its biocompatibility and stability characteristics. Previously, no study has been completed which compares silicone to acrylic cements. In this study, both materials were injected into the cell medium during the curing process which more accurately reflects clinical use of material. Initially, cell cultures followed ASTM standard F813-07 which fails to capture the effects of monomer released during curing. Subsequently, a modified cell culture method was employed which evaluated cytotoxicity while the materials cured. The objective of this study was to capture toxicity data during curing phase. Thus, the test method employed measured and excluded the impact of the exothermic reaction temperature of polymethyl methacrylate (PMMA) on cell growth. The concentration of PMMA monomer was measured at 1 and 24 h after injecting PMMA into culture plat...Continue Reading

References

Apr 1, 1991·Acta Orthopaedica Scandinavica·S Toksvig-LarsenL Ryd
Apr 1, 1994·Acta Orthopaedica Scandinavica·O E DahlT Lyberg
Aug 24, 1999·Bone·D San Millán RuízA M Kurt
Jan 5, 2002·Biomaterials·Paul H WooleySam Nasser
Oct 18, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Weiping RenPaul H Wooley
Jul 23, 2003·International Dental Journal·Peter A Leggat, Ureporn Kedjarune
Jan 16, 2004·Gene Therapy·P H Wooley, E M Schwarz
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·S M Kenny, M Buggy
Nov 16, 2004·The Orthopedic Clinics of North America·Dennis C Smith
Dec 9, 2008·British Journal of Anaesthesia·A J DonaldsonN W Kenny
Oct 30, 2009·Archives of Environmental & Occupational Health·Peter A LeggatUreporn Kedjarune
Jun 1, 2011·Journal of Biomedical Materials Research. Part a·Wei SongDavid C Markel
Jan 23, 2015·A & a Case Reports·José A SastreRafael E Cuello
Dec 1, 2013·Journal of Clinical Orthopaedics and Trauma·Raju VaishyaAbhishek Vaish

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Citations

Jan 29, 2021·Advanced Healthcare Materials·Hyung Joon ShimDae-Hyeong Kim

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