Comparison of in vitro effects of triflusal and acetysalicylic acid on nitric oxide synthesis by human neutrophils

European Journal of Pharmacology
L Sánchez de MiguelA López-Farré

Abstract

Recent studies have suggested that the protective anti-ischemic effects of acetylsalicylic acid are stronger than the inhibition of platelet thromboxane A2 synthesis. Since ischemic events still occur in acetylsalicylic acid-treated patients, the development of new drugs with more powerful protective effects is needed. We compared the effects of a new platelet antiaggregating drug, 2-acetoxy-4-trifluoromethyl-benzoic acid (triflusal) and of acetylsalicylic acid on the interaction between human neutrophils and platelets, examining the capability of neutrophils to generate nitric oxide (NO). Triflusal, in the presence of neutrophils, showed a greater antiplatelet potency than acetylsalicylic acid to inhibit thrombin-induced platelet activation. Significant stimulation of NO-mediated mechanisms in the presence of acetylsalicylic acid or triflusal was demonstrated by the following findings: (1) increased metabolism of arginine to citrulline, (2) increase of cGMP in the platelet/neutrophil system and (3) the inhibitory action of the L-arginine (L-Arg) competitive analogue, NG-nitro-L-arginine-methyl ester (L-NAME), which was reversed by L-Arg. Triflusal increased the stimulation of NO synthesis by neutrophils more than did of acetyl...Continue Reading

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Citations

Jan 28, 2004·Free Radical Biology & Medicine·Andrey A BobkoValery V Khramtsov
Aug 31, 2006·Cardiovascular Drug Reviews·José Antonio González-Correa, José Pedro De La Cruz
Apr 1, 1999·Journal of Hypertension·J I Guerra-CuestaA López-Farré
May 8, 2008·The Journal of Clinical Endocrinology and Metabolism·José-Manuel Fernández-RealWifredo Ricart
May 23, 2003·Journal of the American Society of Nephrology : JASN·Elise CourtoisAntonio López-Farré
Jan 6, 2004·Journal of Pharmaceutical Sciences·M FerritF Martínez

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