PMID: 9192516Jul 1, 1997Paper

Comparison of in vitro response to growth hormone by chondrocytes from mandibular condyle cartilage of young and old mice

Calcified Tissue International
E LivneI Blumenfeld

Abstract

In several aspects the features of aging resemble those of the state of growth hormone (GH) deficiency. Alterations of bone density and increased incidence of osteoporosis are some of the characteristics of aging that are similar to the findings in GH-deficient adults. Osteoarthritis (OA), a nonfatal condition predominating in old age, is characterized by the slowly progressive destruction of articular cartilage of joints. OA lesions are observed in the temporomandibular joint of ICR mice aged 7 months and older. The aim of the present study was to compare the response of chondrocytes from mandibular condyle cartilage of young and old mice to GH and to ascertain whether chondrocytes of old animals could still be stimulated to proliferate and to synthesize matrix components under the direct effect of GH in vitro. Mandibular condyles from young (3-month-old) and old (20-month-old) female ICR mice were cultured up to 72 hours in the presence of recombinant rat GH (0.1-100 ng/ml). 3H-Thymidine and 35S-sulfate were introduced during the last 24 hours of culture. Administration of GH appeared to increase only slightly the incorporation of 3H-thymidine in cartilage from young compared with the response in cartilage from old animals wh...Continue Reading

Citations

Jun 16, 2010·Biogerontology·Amiela Globerson, Abraham Z Reznick
May 28, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·James R VandebergRobert J Hinton
Mar 31, 2009·Cell Biochemistry and Function·C PassC Farquharson
Feb 28, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Maria Luisa TagliaroEmílio Antônio Jeckel-Neto
May 6, 2004·Archives of Oral Biology·German O Ramirez-YañezMichael J Waters
Sep 19, 2006·Experimental Gerontology·Maria Luisa TagliaroEmilio Antônio Jeckel-Neto
Dec 9, 2017·Cartilage·Natalie R DannaEric Strauss
Feb 13, 2015·The Open Dentistry Journal·George Litsas
Jan 6, 2017·Laboratory animal research·Ji Eun KimDae Youn Hwang
Oct 18, 2020·Molecular and Cellular Endocrinology·Manisha DixitShoshana Yakar
Jun 5, 2004·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Jeremy J Mao, Hyun-Duck Nah

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