Comparison of inflammatory responses after off-pump and on-pump coronary surgery using surface modifying additives circuit

The Annals of Thoracic Surgery
Janine M QuaniersJean-Olivier Defraigne

Abstract

Cardiac surgery is followed by various degrees of inflammation, which have harmful consequences. Because of the central role of extracorporeal circulation (EC), off-pump coronary bypass surgery is deemed preferable. Do different modalities of EC challenge this view? Four groups of similar patients underwent coronary surgery: (group 1) on-pump, EC with closed surface modifying additives (SMA) circuit and no pump suckers (n = 20); (group 2) on-pump, EC with open SMA circuit and pump suckers (n = 20); (group 3) off-pump (beating heart) and heparin 3 mg/kg (n = 20); (group 4) off-pump (beating heart) and heparin 1 mg/kg (n = 20). Interleukins (IL)-6, IL-8, IL-10, myeloperoxidase, elastase, and terminal complex of the complement (TCC) were analyzed at various times: at induction (time I); after heparin (time II); after complete revascularization (time III); after protamine (time IV); and 24 hours later (time V). The TCC was significantly higher in groups 1 and 2 at time III. The pattern of IL-6 was the same for the four groups. No significant difference in myeloperoxydase content was noted; however, elastase was significantly higher in the two EC (on-pump) groups. Except for the complement system and elastase, on-pump surgery with S...Continue Reading

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Citations

Jul 9, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Jacobo SilvaEnrique Rodríguez
Jun 25, 2008·The Annals of Thoracic Surgery·Matthias SiepeChristian Schlensak
Oct 24, 2007·British Journal of Pharmacology·M-S SuleimanG D Angelini
Apr 14, 2015·Disease Markers·Gerwin Erik Engels, Willem van Oeveren
Aug 23, 2011·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jennifer A ColbyC Michael White
Sep 16, 2015·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·John D PuskasVipin Zamvar
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Christian H MøllerChristian Gluud
Apr 13, 2010·The International Journal of Artificial Organs·Thomas RimmeléJohn A Kellum

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