Abstract
In this paper, we investigated the inhibitory mechanism of the production of nitric oxide (NO) by polyanions and liposomes composed of phosphatidylserine (PS-liposomes) focusing on cytokine production and mitogen activated protein kinase (MAP kinase) activation. NO production by macrophages was inhibited by treatment with oxidized lipoprotein (OxLDL), maleylated bovine serum albumin (mBSA), and heparin. No inhibitory effect was exhibited by poly-cytidilic acid (PolyC). To clarify the mechanism of the inhibitory effect of polyanions on NO production, we evaluated the productions of transforming growth factor-beta (TGF-beta) and interleukin (IL)-10 which are known to be anti-inflammatory cytokines. TGF-beta was produced when macrophages were treated with OxLDL as was the case with PS-liposomes. No increase in TGF-beta production was observed for mBSA, heparin, and PolyC. On the other hand, significant production of IL-10 was observed using mBSA. Extracellular signal-regulated kinase (ERK), a member of the MAP kinase superfamily, was activated when macrophages were treated with OxLDL as well as PS-liposomes. In the case of mBSA, the activation of ERK and c-Jun N-terminal kinase (JNK) was observed. No activation of p38 MAP kinase w...Continue Reading
References
Nov 1, 1991·Infection·R WeberR Lüthy
Sep 1, 1991·Infection and Immunity·D J FastR W Leu
Sep 1, 1991·Infection and Immunity·I E Flesch, S H Kaufmann
May 1, 1989·The Journal of Experimental Medicine·D J Stuehr, C F Nathan
May 15, 1987·Cancer·M MoriT Ooiwa
Feb 1, 1994·Circulation Research·X YangP J Cannon
Apr 15, 1994·Biochemical and Biophysical Research Communications·S E ChesrownH S Nick
Jan 27, 1995·The Journal of Biological Chemistry·M FukasawaK Inoue
Jan 10, 1996·Experimental Cell Research·M FukasawaK Inoue
Mar 7, 1996·Biochemical and Biophysical Research Communications·Y AramakiS Tsuchiya
Nov 1, 1996·The Journal of Biological Chemistry·M SakaiS Horiuchi
Apr 1, 1997·Nature Medicine·L BenimetskayaC A Stein
Aug 28, 1997·Biochemical and Biophysical Research Communications·R MatsunoS Tsuchiya
Oct 23, 1997·Journal of Leukocyte Biology·I SeylerG Barratt
Mar 26, 1998·Biochemical and Biophysical Research Communications·R MatsunoS Tsuchiya
Aug 26, 1998·Cellular and Molecular Life Sciences : CMLS·Y YamadaT Kodama
Apr 2, 1999·European Journal of Biochemistry·D RhaindsL Brissette
May 16, 2000·Nature·V A FadokP M Henson
Jun 23, 2000·Biological & Pharmaceutical Bulletin·T NakamuraJ Watanabe
Mar 10, 2001·Biochemical and Biophysical Research Communications·R MatsunoS Tsuchiya
May 23, 2002·The Journal of Biological Chemistry·Yuki KawasakiYoshinobu Nakanishi
Feb 25, 2003·The American Journal of Pathology·Yuben MoodleyDarryl Knight
Jul 29, 2004·Journal of Cellular Physiology·Michelle AlexanderMartin G Schwacha
Sep 3, 2004·Yonsei Medical Journal·Yong-Suk RyangJu-Youn Park
Sep 11, 2004·Biochemical and Biophysical Research Communications·Young-Hun YookHayyoung Lee
Oct 27, 2004·Biochemical and Biophysical Research Communications·Masaki OtsukaYukihiko Aramaki
Citations
Jan 11, 2014·International Immunopharmacology·Rui TadaYukihiko Aramaki
May 10, 2008·Digestive Diseases and Sciences·Giuseppe CelascoRoberto Di Marco
Nov 7, 2009·Alimentary Pharmacology & Therapeutics·G CelascoG Gasbarrini
Jul 1, 2020·Advanced Healthcare Materials·Sufeng ZhangGiovanni Traverso