Comparison of Insulin Resistance to Coronary Atherosclerosis in Human Immunodeficiency Virus Infected and Uninfected Men (from the Multicenter AIDS Cohort Study)

The American Journal of Cardiology
Michael I BrenerT Brown

Abstract

The relation between insulin resistance (IR) and coronary artery disease in patients with human immunodeficiency virus (HIV) infection remains incompletely defined. Fasting serum insulin and glucose measurements from 448 HIV-infected and 306 uninfected men enrolled in the Multicenter AIDS Cohort Study were collected at semiannual visits from 2003 to 2013 and used to compute the homeostatic model assessment of IR (HOMA-IR). Coronary computed tomographic angiography (CTA) was performed at the end of the study period to characterize coronary pathology. Associations between HOMA-IR (categorized into tertiles and assessed near the time of the CTA and over the 10-year study period) and the prevalence of coronary plaque or stenosis ≥50% were assessed with multivariate logistic regression. HOMA-IR was higher in HIV-infected men than HIV-uninfected men when measured near the time of CTA (3.2 vs 2.7, p = 0.002) and when averaged over the study period (3.4 vs 3.0, p <0.001). The prevalence of coronary stenosis ≥50% was similar between both groups (17% vs 15%, p = 0.41). Both measurements of HOMA-IR were associated with greater odds of coronary stenosis ≥50% in models comparing men with values in the highest versus the lowest tertiles, alt...Continue Reading

References

Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·A KatzM J Quon
Aug 11, 2005·The Journal of Clinical Endocrinology and Metabolism·Christoph H SaelyHeinz Drexel
Apr 20, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alexandra MangiliChristine A Wanke
Aug 20, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kathleen V FitchSteven Grinspoon
Sep 22, 2010·PloS One·H Irene HallUNKNOWN Urban Areas HIV Surveillance Workgroup
Feb 16, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Alexander VonbankHeinz Drexel
Jun 7, 2011·The International Journal of Cardiovascular Imaging·Giovanni GuaraldiPaolo Raggi
Feb 5, 2013·Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology·Yalçın HacıoğluMatthew J Budoff
Aug 16, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Gretchen E VolpeChristine A Wanke
Mar 26, 2014·Nature Reviews. Endocrinology·Markku Laakso, Johanna Kuusisto
Apr 2, 2014·Annals of Internal Medicine·Wendy S PostLisa P Jacobson

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