Comparison of insulin sensitivity in patients with insulinoma and obese Type 2 diabetes mellitus

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
J SkrhaV Justová

Abstract

Insulin sensitivity was evaluated in 16 insulinoma patients and in 15 obese persons with Type 2 diabetes mellitus by using hyperinsulinaemic clamps and analysis of insulin receptor characteristics on erythrocytes. Significantly decreased insulin sensitivity index (M/l) was found in both insulinoma and obese Type 2 diabetic patients as compared with healthy non-obese controls (21.2 +/- 2.2 and 19.5 +/- 2.6 vs 40.3 +/- 3.7 mumol.kg-1.min-1 per mU.l-1 x 100, p < 0.001). No difference was observed between both groups of patients. Metabolic clearance rate of glucose was strongly reduced in obese diabetic patients but it was normal in insulinoma patients in comparison with healthy persons (2.7 +/- 0.4 vs 8.7 +/- 0.6 or 7.9 +/- 0.7 ml.kg-1.min-1, p < 0.001). A decreased insulin binding on specific receptors caused by reduced binding capacity was observed only in insulinoma patients but not in obese Type 2 diabetic patients. A significant negative correlation was proved between body mass index (BMI) and insulin sensitivity index (r = -0.82, p < 0.001) indicating that BMI is the main determining factor of insulin resistance in the total cohort of examined patients. We conclude that insulin resistance was caused by postreceptor changes i...Continue Reading

Citations

Mar 18, 2003·Diabetes Research and Clinical Practice·Takashi NagaiMasatomo Mori
Jul 22, 1999·Diabetes Research and Clinical Practice·J SkrhaJ Hilgertová
Mar 23, 2000·The Journal of Clinical Investigation·J C DevedjianF Bosch
Jan 6, 2006·Environmental Health Perspectives·Paloma Alonso-MagdalenaAngel Nadal
Mar 27, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·C J Schofield, C Sutherland
Jun 10, 2008·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Prakash SeshadriWarren Butt
Nov 28, 2012·Life Sciences·M M BonaventuraV A Lux-Lantos
Jun 30, 2006·Medical Hypotheses·E Y MorrisonS A Peter
Sep 13, 2016·Diabetes, Obesity & Metabolism·A HelmanY Dor
Dec 13, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eman AwadHelga Stopper
Nov 5, 1997·Annals of the New York Academy of Sciences·J SkrhaJ Hilgertová
Nov 1, 2007·American Journal of Physiology. Endocrinology and Metabolism·M M BonaventuraV A Lux-Lantos

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