PMID: 9159820May 1, 1997Paper

Comparison of integrin alpha chain expression in benign and malignant salivary gland tumors

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
A FranchiR Bondi

Abstract

This study investigates the distribution of the alpha chain of the integrin family of extracellular matrix receptors in a series of adenomas and carcinomas of salivary gland origin to determine if the malignant phenotype is associated with modification of the expression of these receptors. Cryostat sections of 36 tumor specimens were stained by a standard streptavidin-biotin-peroxidase technique using primary monoclonal antibodies against alpha 1-6 and alpha v integrin chains. The immunohistochemical reaction was scored using a three-point scale and the results were analyzed using Fisher's exact test. In salivary adenomas, alpha 2, alpha 3, alpha 4, alpha 6, and alpha v chains were widely expressed in most of the cases studied. The alpha 1 subunit was prominently expressed by the epithelial cells of Warthin's tumor, whereas a minority of pleomorphic adenomas showed immunoreactivity for this antigen. We observed alpha 5 subunit expression only in the mesenchymal-like component of pleomorphic adenomas. In salivary carcinomas, integrin alpha chain expression was heterogeneous, varying greatly between different histotypes and within the same histotype. The distribution of the antigens was similar to that of adenomas, except for the...Continue Reading

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Citations

Feb 20, 2010·International Journal of Otolaryngology·Tarik El-HadiM Kzadri
Apr 16, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S V L LoduccaV C Araújo
Dec 22, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mohsin MalikA Razzaque Ahmed
Aug 23, 2005·International Journal of Oral and Maxillofacial Surgery·A J Lyons, J Jones X-T Xie
Jun 25, 2008·International Journal of Surgical Pathology·Emanuel Sávio de Souza AndradeLélia Batista de Souza

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