Comparison of internal emitter radiobiology in animals and humans

Health Physics
R D LloydW S Jee

Abstract

Investigations of radionuclide metabolism and effects in various mammalian species revealed important similarities between animals and humans and between some animal species. These include skeletal deposition of radium and radiostrontium in bone volume; deposition on bone surfaces of plutonium and other actinides; liver deposition of actinides; induction of skeletal or liver malignancies by these radionuclides; induction of tooth and jaw abnormalities; mammary cancer induction by radium in humans and in the beagle; depression of circulating cells in blood; and induction of bone fractures. There are also inter-species differences that may not have been noted if multiple species (including humans) had not been studied. Some of these are more rapid excretion of radium in humans compared with most other mammals; induction by radium of eye melanomas in animals but not humans; rapid loss of deposited plutonium from liver in many species of mice and rats but not in humans and dog; substantial sex-related differences in skeletal plutonium retention and bone sarcoma induction in mice but not in humans or dog; and induction of head sinus carcinomas by 226Ra in humans but not the beagle. Leukemia and other related neoplasms were not induc...Continue Reading

Citations

Apr 13, 2005·Health Physics·R D LloydW S S Jee
Apr 12, 2006·Health Physics·A LucianiS C Miller
Mar 25, 2008·Journal of Environmental Radioactivity·Roongrat PetersenElo Harald Hansen
Sep 25, 2004·Radiation Research·Harmen BijwaardHenk P Leenhouts
Oct 30, 2016·Journal of Environmental Radioactivity·Tatiana G Sazykina, Alexander I Kryshev

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