Comparison of intralesionally injected zinc sulfate with meglumine antimoniate in the treatment of acute cutaneous leishmaniasis

Dermatology : International Journal for Clinical and Investigative Dermatology
F IrajiAli Z Momeni

Abstract

Cutaneous leishmaniasis is an endemic disease in developing countries. The first-line drugs for its treatment are the pentavalent antimony compounds such as meglumine antimoniate (MA). High cost, side effects, multiple injections and incomplete efficacy are limitations of this therapy. Zinc sulfate (ZS) has been reported to be effective in the treatment of cutaneous leishmaniasis. To compare the efficacy of intralesional injections of ZS 2% with those of MA in the treatment of cutaneous leishmaniasis. This was a prospective, double-blind, case-control clinical study. 104 patients with typical lesions of acute cutaneous leishmaniasis (ACL) were included. The duration of treatment was 6 weeks. Improvement was evaluated by clinical examination and direct smear. The study was completed in only 66 patients: 35 patients received MA and 31 received ZS. The cure rates were 60% for MA and 83.8% for ZS. After the second and fourth weeks, the efficacy of treatment with ZS was higher than that with MA (p < 0.01), but after 6 weeks no significant differences were observed between the two groups (p > 0.05). On the basis of this trial and despite the high number of drop-outs, we consider that the intralesional injection of ZS 2% is an alterna...Continue Reading

Citations

Jul 13, 2011·Dermatology Research and Practice·Mohamad Javad YazdanpanahHadis Yousefzadeh
May 3, 2014·PLoS Neglected Tropical Diseases·Caspar J HodiamontTom van Gool
Dec 9, 2014·Jundishapur Journal of Microbiology·Ali Fattahi BafghiMahdi Aghabagheri
Aug 15, 2014·Dermatology Research and Practice·Mrinal GuptaPushpinder S Chauhan
Mar 30, 2013·Journal of Infection and Public Health·Mahmoud MohammadzadehZahra Golshan
Jun 1, 2010·Dermatologic Clinics·Yoon Soo BaeArnon D Cohen
Mar 6, 2007·Journal of the American Academy of Dermatology·Alireza KhatamiYahya Dowlati
Sep 15, 2006·The Journal of Dermatological Treatment·Yuval Bibi Nitzan, Aanon D Cohen
Nov 18, 2017·The Cochrane Database of Systematic Reviews·Julio Heras-MosteiroRogelio López-Vélez
Dec 2, 2017·The Cochrane Database of Systematic Reviews·Julio Heras-MosteiroRogelio López-Vélez
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Urbà GonzálezJorge Alvar
Jun 22, 2019·Current Pharmaceutical Design·Victoria WagnerChristopher Fernández-Prada

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.