Comparison of intranasal and transdermal estradiol on nasal mucosa in postmenopausal women

Menopause : the Journal of the North American Menopause Society
C NappiVieri Galli

Abstract

To compare nasal symptomatology and function and local concentrations of estradiol (E2), estradiol receptor (ERalpha), vasoactive intestinal peptide (VIP), substance P (SP) and neuropeptide Y (NPY) in nasal biopsies of 20 postmenopausal women complaining of paradoxical nasal stuffiness before and after treatment with intranasal or transdermal E2. Twenty healthy postmenopausal women willing to start hormone therapy (HT) were allocated to one of two groups, using a computer-generated randomization list. Ten postmenopausal women were treated with transdermal 17beta-estradiol 50 microg daily plus nomegestrole acetate 5 mg/day for 12 days per 28-day cycle for 6 months (Group A). Ten postmenopausal women were treated with intranasal 17beta-estradiol 300 microg/day (one spray delivery of 150 microg per nostril) plus nomegestrole acetate 5 mg/day for 12 days per 28-day cycle for 6 months (Group B). Fourteen fertile women undergoing nasal mucosa biopsy during plastic surgery were used as controls for the immunohistochemical evaluation (Group C). All women in groups A and B underwent evaluation of nasal stuffiness score, mucociliary transport time, rhinoscopy, and active anterior rhinomanometry at the beginning of the study and after, VI...Continue Reading

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Citations

Dec 13, 2006·Clinical Allergy and Immunology·A Asli Sahin-Yilmaz, Jacquelynne P Corey
Feb 10, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Antonietta RossiRaffaele Capasso
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Mar 3, 2012·Logopedics, Phoniatrics, Vocology·Evelien D'haeseleerKristiane Van Lierde
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Aug 6, 2020·International Journal of Molecular Sciences·Marisa PalazzoCiro Costagliola

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