PMID: 18203086Jan 19, 2008Paper

Comparison of intraocular pressure lowering effect of once daily morning vs evening dosing of latanoprost/timolol maleate combination

European Journal of Ophthalmology
T TakmazI Can

Abstract

To compare intraocular pressure (IOP) reduction profiles of latanoprost-timolol maleate fixed combination (LTFC) administered in the morning or evening in primary open angle glaucoma (POAG). A prospective, randomized study including 60 eyes of 30 patients with POAG was carried out. Patients were randomized to treatment with LTFC at 8 PM (Group 1) or at 8 AM (Group 2). After therapy of 4 weeks, IOP was measured at 2 AM, 6 AM,10 AM, 2 PM, 6 PM, and 10 PM and compared with baseline values and latanoprost therapy alone. Mean diurnal baseline IOPs and IOPs after treatment with latanoprost and LTFC were 23.6+/-2.6, 16.7+/-2.3, and 15.5+/-2.2 mmHg in Group 1 and 23.1+/-2.6, 16.9+/-2.4, and 15.7+/-2.4 mmHg in Group 2. LTFC lowered IOP more than latanoprost at all time points in both groups (p<0.001) (except 6 AM in Group 2). The mean IOP range after LTFC therapy was lower than the baseline in Group 1 whereas it was not different in Group 2. IOP at 10 AM was significantly higher than the other time points at baseline measurements in both groups (p<0.01) but after treatment there was no difference (p>0.05). According to IOP reduction from baseline, there was a statistically significant difference between groups in favor of Group 1 at 6 A...Continue Reading

References

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Citations

Jan 19, 2013·International Journal of Clinical Pharmacy·Gagandeep KaurBandana Saini
Oct 21, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Kenji InoueGoji Tomita
Feb 11, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Mumin Hakan ErenSenol Sabanci
Oct 9, 2018·Expert Opinion on Pharmacotherapy·Rebecca Russ Soares, M Reza Razeghinejad
Jun 29, 2013·Expert Opinion on Pharmacotherapy·Anastasios Gp KonstasMurat Irkec
Apr 29, 2016·Expert Opinion on Pharmacotherapy·Anastasios G P Konstas, Gabor Holló
Jan 7, 2021·Expert Opinion on Investigational Drugs·Tina Guanting Qiu
Feb 26, 2009·Current Opinion in Ophthalmology

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