Comparison of intraoperative versus intraoperative plus postoperative hemoadsorption therapy in cardiac surgery patients with endocarditis

The International Journal of Artificial Organs
Lars-Uwe KühneFriedrich-Christian Rieß

Abstract

Infective endocarditis is caused by a bacterial infection of the endocardial surface, and despite improvements in surgical interventions and antimicrobial therapy, mortality remains high. Recently published data suggest that intraoperative hemoadsorption therapy might represent a promising treatment option; however, randomized data still lack, and a comparative study on the intraoperative versus intraoperative plus postoperative use of CytoSorb has not yet been performed. We hypothesized that patients developing intraoperative renal failure benefit from additional postoperative CytoSorb treatment in terms of outcome. We examined the application of hemoadsorption therapy in 20 endocarditis patients separated into two groups: (1) sole intraoperative versus (2) intraoperative plus postoperative treatment, with regard to inflammatory and hemodynamic status, the postoperative course including development of complications, extent of extracorporeal organ support, and outcome. Despite an obviously more pronounced disease severity in the intraoperative plus postoperatively treated patients as evidenced by a higher initial European System for Cardiac Operative Risk Evaluation score, higher reoperation rate, longer cardiopulmonary bypass ...Continue Reading

References

Jun 1, 1996·The Annals of Thoracic Surgery·J CremerH G Borst
Sep 25, 2007·Interactive Cardiovascular and Thoracic Surgery·Jorge IbáñezOriol Bonnin
Oct 13, 2009·International Anesthesiology Clinics·Sean A Josephs, Charuhas V Thakar
Jan 29, 2013·Critical Care Medicine·R Phillip DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup
Aug 2, 2013·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Hiroyuki KamiyaMatthias Karck
Dec 9, 2014·Current Opinion in Anaesthesiology·Alan M Gaffney, Robert N Sladen
Oct 8, 2016·Annals of Cardiac Anaesthesia·Christian Ortega-LoubonEnrique Fulquet-Carreras
Nov 26, 2016·The Annals of Thoracic Surgery·Todd C CrawfordGlenn J Whitman
May 20, 2017·The International Journal of Artificial Organs·Karl TrägerHelmut Reinelt

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Software Mentioned

CytoSorb
GraphPad Prism

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