Comparison of intraplatelet reactive oxygen species, mitochondrial damage, and platelet apoptosis after implantation of three continuous flow left ventricular assist devices: HeartMate II, Jarvik 2000, and HeartWare

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Nandan K MondalZhongjun J Wu

Abstract

Differences in device design may have an effect on platelet damage and associated clinical complications. We aimed to compare device-specific platelet functionality in 26 heart failure patients supported with three continuous-flow left ventricular assist devices: HeartMate II (n = 8), Jarvik 2000 (n = 9), and HeartWare (n = 9). Intraplatelet reactive oxygen species (ROS) generation, mitochondrial damage, and platelet apoptosis were compared between device types before and after the implantation at every week up to 1 month. Overall, the baseline characteristics, demographics, routine laboratory values were comparable between the three device groups. Intraplatelet ROS, mitochondrial damage, and platelet apoptosis significantly elevated in the HeartWare group in comparison with the other two device groups after implantation. The major bleeding, infections, systemic inflammatory response syndrome, and right ventricular failure were found to be more common among the HeartWare group than others. Intraplatelet ROS and platelet damage levels were returned to baseline in both the HeartMate II and the Jarvik groups, whereas in HeartWare group they remained elevated. The patients with the Jarvik and the HeartMate II experienced less clini...Continue Reading

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Citations

Oct 21, 2016·Journal of Thrombosis and Haemostasis : JTH·P LukitoA K Davis
Jan 13, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Craig H SelzmanStephen H McKellar
Jan 9, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Guang-Mao LiuXing-Min Gui
Jun 18, 2017·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Masahiro Nishida
Apr 29, 2021·The International Journal of Artificial Organs·Guang-Mao LiuSheng-Shou Hu
Aug 13, 2021·The International Journal of Artificial Organs·Guang-Mao LiuSheng-Shou Hu

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