Comparison of intraurethral liposomal and intracavernosal prostaglandin-E1 in the management of erectile dysfunction

British Journal of Urology
P F EngelhardtH Pflüger

Abstract

To compare the intraurethral application of liposomal prostaglandin-E1 (PGE1) with intracavernosal injection of PGE1 in patients with organic or psychogenic erectile dysfunction (ED). Penile tumescence and rigidity were classified by palpation in 25 patients (10 with psychogenic and 15 with organic ED: median age 45 years, range 23-67). All patients were undergoing primary treatment for ED, the median (range) duration of which was 2 3 (2-44) months. After administering PGE1 by each route (1 mg intraurethral and 0.02 or 0.01 mg intracavernosal), the degree of erection was assessed and duplex ultrasonography of the deep penile artery was performed. After the intraurethral application of liposomal PGE1, there was mild penile tumescence in 12 patients with organic ED, the others having no response. In contrast, intracavernosal injection produced sufficient rigidity in 13 patients with organic ED, while two only had a slight increase in tumescence. In patients with psychogenic ED, intraurethral application gave adequate rigidity in six, with four having little or no tumescence, and intracavernosal injection induced sufficient rigidity for intercourse in all. Duplex ultrasonography of the deep penile artery of the penis showed that i...Continue Reading

References

Oct 1, 1992·Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology·Y KawanishiS Kagawa
Jul 1, 1988·The Journal of Urology·W StacklM Marberger
Jan 1, 1994·The Clinical Investigator·O I Linet, L L Neff

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Citations

Feb 13, 2004·International Journal of Impotence Research·T BschleipferC Sparwasser

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