Comparison of intrauterine insemination with timed intercourse in superovulated cycles with gonadotropins: a meta-analysis

Fertility and Sterility
Hulusi Bulent ZeynelogluA J Duleba

Abstract

To compare timed intercourse and IUI with the husband's sperm in patients with unexplained infertility who are undergoing superovulation with gonadotropins. Meta-analysis. All published reports of randomized, prospective studies with an English-language abstract extracted from MEDLINE were analyzed. A crossover search was done from the papers obtained. Academic center. Couples with unexplained infertility. Meta-analysis of studies evaluating patients superovulated with gonadotropins and randomized for timed intercourse or IUI. Pregnancy rates (PRs) were obtained. The common odds ratio (OR) and 95% confidence intervals (95% CI) were calculated. There were 49 pregnancies in 431 cycles of timed intercourse (11.37%), whereas there were 110 pregnancies in 549 cycles of IUI (20.04%). The PRs for IUI were significantly increased compared with those for timed intercourse in superovulation cycles (common OR = 1.84; 95% CI = 1.30-2.62). On the basis of the meta-analysis of 980 cycles in randomized and prospective studies, a patient's chances of becoming pregnant are greater with IUI with her husband's sperm than with timed intercourse in cycles superovulated with gonadotropins.

References

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Citations

Jun 29, 2011·Archives of Gynecology and Obstetrics·Syed Monajatur RahmanSunesh Kumar
May 12, 2004·Fertility and Sterility·Gilberto IbéricoRafael Bernabeu
Mar 2, 2002·Fertility and Sterility·Florence LesourdJean Parinaud
May 7, 2004·Current Opinion in Obstetrics & Gynecology·Hulusi Bulent Zeyneloglu
Jan 25, 2011·The Journal of Reproduction and Development·Klaus-Peter BrüssowJozsef Rátky
Dec 28, 2010·Journal de gynécologie, obstétrique et biologie de la reproduction·A Amar-HoffetJ Belaisch-Allart
Feb 24, 2016·Fertility and Sterility·Deidre D Gunn, G Wright Bates
May 12, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Luisa CasadeiEmilio Piccione
Apr 20, 2004·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Michael F Costello
Aug 24, 1999·American Journal of Obstetrics and Gynecology·M A AboulgharA Kamal
Mar 4, 2020·The Cochrane Database of Systematic Reviews·Reuben Olugbenga AyelekeSusanne M Veltman-Verhulst
Jul 19, 2003·Human Fertility : Journal of the British Fertility Society·Ian Russell, Daphne Russell
Feb 20, 2016·The Cochrane Database of Systematic Reviews·Susanne M Veltman-VerhulstBen J Cohlen

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