Comparison of intravenous and topical lidocaine as a suppressant of coughing after bronchoscopy during general anesthesia

Acta Anaesthesiologica Scandinavica
C J JakobsenA Thomsen

Abstract

Twenty-four consecutive patients scheduled for fiberbronchoscopy were randomized to receive double-blind either intravenous (1.5 mg/kg) or laryngotracheal (3 mg/kg) lidocaine to evaluate the influence on post-bronchoscopic laryngospasm, pain in the throat and coughing. Plasma lidocaine concentrations were analyzed 5, 15, 30 and 60 min after administration. None of the patients demonstrated laryngospasm or pain in the throat during the first hour after bronchoscopy. Patients receiving topical lidocaine coughed significantly more than patients receiving intravenous lidocaine, with a median number of coughs of 20 compared to 4, during the first hour (P less than 0.01). The plasma lidocaine concentrations were significantly higher after intravenous than after topical administration (P less than 0.001). After intravenous administration the plasma lidocaine concentrations exceeded the accepted level for potential toxicity in five out of 11 patients, but none of the patients developed toxic symptoms and no side-effects were observed.

References

Jul 1, 1979·Clinical Pharmacokinetics·G T Tucker, L E Mather
May 1, 1979·Anesthesiology·T J Poulton, F M James
Sep 1, 1978·Canadian Anaesthetists' Society Journal·A V BidwaiV A Bidwai
Dec 1, 1985·Anesthesia and Analgesia·H YukiokaM Fujimori
Dec 1, 1985·Anesthesia and Analgesia·P LeichtB Chraemmer-Jørgensen
Nov 1, 1983·Anesthesiology·M Kawamoto, Y Shimidzu
Feb 1, 1983·Anaesthesia and Intensive Care·R L EyresT C Brown
Jan 1, 1982·Thorax·J EfthimiouG M Cochrane
Apr 1, 1980·Acta Anaesthesiologica Scandinavica·P H RosenbergM Takasaki
Mar 1, 1958·Anesthesia and Analgesia·J E STEINHAUS, D E HOWLAND
May 1, 1963·Anesthesiology·J E STEINHAUS, L GASKIN

Citations

Mar 3, 2009·Cephalalgia : an International Journal of Headache·R Gil-Gouveia, P J Goadsby
Mar 1, 1995·Annals of Emergency Medicine·M Rabold, J Tintinalli
Feb 24, 2001·Respiratory Medicine·I Matot, M R Kramer
Jul 2, 2011·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jeremy P Hampton
Mar 29, 2014·Pharmacological Reviews·P V DicpinigaitisC P Page

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.