Comparison of intravenous nitroglycerin and sodium nitroprusside in acute myocardial infarction

The American Journal of Medicine
J T Flaherty

Abstract

Initial studies from our institution demonstrated beneficial anti-ischemic effects of short-term infusion of intravenous nitroglycerin in patients with acute myocardial infarction. At lower doses, nitroglycerin was shown to be principally a venodilator; at higher doses, a mixed venous and arterial dilating effect was demonstrated. The acute hemodynamic effects of nitroglycerin varied in the presence or absence of left ventricular failure; patients with the most severe degree of left ventricular dysfunction had the most beneficial hemodynamic effect. Similar differential effects have been demonstrated for nitroprusside in other studies. A comparison of the arterial vasodilating potency of nitroglycerin and nitroprusside in patients in whom acute hypertension develops following coronary artery bypass surgery revealed that equal lowering of arterial pressure and systemic vascular resistance could be demonstrated in 85 percent of the patients with comparable infusion rates. Review of previous clinical and laboratory studies in animals, in which the effects of nitroglycerin and nitroprusside were compared, in most cases revealed opposite effects on intercoronary collateral flow and, thereby, opposite effects on the severity of regio...Continue Reading

References

Jan 1, 1975·Circulation·J T FlahertyB Pitt
May 13, 1982·The New England Journal of Medicine·J D DurrerD Durrer

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Citations

May 17, 2003·Drugs & Aging·Kourosh MoazemiAbraham G Kocheril
Oct 16, 2009·Journal of Medical Case Reports·Maya Guglin, Gilbert Postler
Aug 1, 1988·American Heart Journal·W M BreisblattL J Spaccavento
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Jan 1, 1988·Catheterization and Cardiovascular Diagnosis·M L Carr
Jan 1, 1986·Acta Pharmacologica Et Toxicologica·B W Johansson

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