PMID: 3757766Jul 1, 1986Paper

Comparison of intravenously administered methadone, morphine and heroin

Drug and Alcohol Dependence
D R Jasinski, K L Preston

Abstract

Data from previously reported studies suggest that methadone may be more euphorigenic than other morphine-like drugs. To determine whether methadone is more potent in producing euphoria relative to its other opiate-like effects, single doses of intravenously administered methadone, morphine, heroin and placebo were compared in non-dependent post-addict volunteers. Morphine-like physiologic, subjective and behavioral effects were measured periodically for 24 h after drug administration. Under the conditions of the experiment methadone produced a profile of effects which was indistinguishable from that of morphine and heroin. Only the time course of miosis, which was longer lasting following methadone, differentiated among the three compounds. The relative potencies of methadone, morphine and heroin for the initial 5 h of effect were constant over all opiate-like effects, including measures of euphoria. Thus, methadone was not a selective euphoriant.

References


❮ Previous
Next ❯

Citations

Oct 6, 2006·European Journal of Clinical Pharmacology·Liliana BachsJørg Mørland
May 1, 1992·Pharmacology, Biochemistry, and Behavior·T L PierceJ E Olley
May 21, 1998·European Journal of Pharmacology·S D ComerM W Fischman
May 30, 1987·Lancet·M L CitronS Fleishman
Jun 22, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sandra D ComerWilliam J Kowalczyk
Dec 1, 1991·British Journal of Addiction·G E Bigelow
Dec 27, 2005·Journal of Substance Abuse Treatment·Marica FerriCarlo A Perucci
Dec 12, 2012·Journal of Pain & Palliative Care Pharmacotherapy·Gary M Reisfield, Charles K Friedman
Dec 15, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·G GerraL Somaini
Jun 12, 2014·Expert Review of Clinical Pharmacology·Eric L Garland
Sep 25, 2007·The American Journal of Drug and Alcohol Abuse·Alexander M Ponizovsky, Alexander Grinshpoon
Mar 1, 1995·Clinical Pharmacology and Therapeutics·H L JuneE Cone
Dec 14, 2011·The Cochrane Database of Systematic Reviews·Marica FerriCarlo A Perucci
Jul 1, 1990·DICP : the Annals of Pharmacotherapy·S K Guthrie
Mar 27, 2019·The Journal of Clinical Investigation·Ning-Sheng CaiSergi Ferré

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.