Comparison of Intravitreal Aflibercept and Ranibizumab following Initial Treatment with Ranibizumab in Persistent Diabetic Macular Edema

Journal of Ophthalmology
Ali DemircanBurcu Kemer

Abstract

To compare the visual and anatomic outcomes in patients with persistent diabetic macular edema (DME) who switched from ranibizumab to aflibercept with those who continued with previous ranibizumab therapy. In this retrospective comparative study, medical records of consecutive patients with center-involved DME ≥ 350 μm who had at least three recent consecutive monthly ranibizumab injections followed by as-needed therapy with either aflibercept or ranibizumab were reviewed. Data were collected at presentation (preinjection), at the intermediary visit, and at the last visit (at the end of the follow-up period). Forty-three eyes of 43 patients were divided into two groups: the switch group (n = 20) and the ranibizumab group (n = 23). Though no significant improvement was found in the mean BCVA from the intermediary visit to the last visit, there was a difference in the mean CMT in the switch group and the ranibizumab group (p < 0.001 and p = 0.03, resp.). The mean CMT decreased after the intermediary visit by 188.6 ± 120.5 μm in the switch group and by 60.3 ± 117.1 μm in the ranibizumab group (p = 0.003). Both aflibercept and ranibizumab decreased CMT in patients with persistent DME who showed a poor response to ranibizumab inject...Continue Reading

References

Jun 18, 1999·American Journal of Ophthalmology·T OtaniY Maruyama
Feb 25, 2003·Progress in Retinal and Eye Research·A N WitmerR O Schlingemann
Jan 2, 2004·The New England Journal of Medicine·Robert N Frank
Aug 4, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Lihteh WuUNKNOWN Pan American Collaborative Retina Group (PACORES)
Aug 19, 2007·Ophthalmology·UNKNOWN Diabetic Retinopathy Clinical Research NetworkCynthia R Stockdale
Apr 30, 2010·Ophthalmology·UNKNOWN Diabetic Retinopathy Clinical Research NetworkJennifer K Sun
Feb 4, 2012·Diabetes Care·Joanne W Y YauUNKNOWN Meta-Analysis for Eye Disease (META-EYE) Study Group
Feb 15, 2012·Ophthalmology·Quan Dong NguyenUNKNOWN RISE and RIDE Research Group
Apr 17, 2014·Investigative Ophthalmology & Visual Science·Uri SoibermanDafna Goldenberg
Oct 9, 2015·Investigative Ophthalmology & Visual Science·Kyle KovacsJorge G Arroyo
Jan 10, 2016·American Journal of Ophthalmology·Ehsan RahimyJason Hsu
Feb 27, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Bobak BahramiAndrew Chang
Apr 5, 2017·International Journal of Retina and Vitreous·Kendra A KleinElias Reichel

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