Comparison of intravoxel incoherent motion diffusion-weighted MR imaging with dynamic contrast-enhanced MRI for differentiating lung cancer from benign solitary pulmonary lesions

Journal of Magnetic Resonance Imaging : JMRI
Mei YuanJiang-Fen Wu

Abstract

To compare intravoxel incoherent motion (IVIM) and pharmacokinetic analysis dynamic contrast-enhanced MR imaging (DCE-MRI) in distinguishing lung cancer (LC) from benign solitary pulmonary lesions (SPL). This prospective study was approved by the institutional review board, and written informed consent was obtained. Eighty-one consecutive patients considered for SPL underwent DW-IVIM and DCE-3T MRI. ADC, D, D*, and f were calculated with mono- and bi-exponential models. K(trans) , kep , ve , and vp were calculated with the modified Tofts model. Receiver operating characteristic (ROC) analysis was constructed to determine the diagnostic performance of IVIM and DCE-MRI in discriminating LC from benignity. There were 29 patients with a total of 48 benign SPL and 52 LCs: 4 small cell carcinomas (SCLC), 19 squamous cell carcinomas (SCC), and 29 adenocarcinomas (Adeno-Ca). Both Adeno-Ca (ADC: 1.19 ± 0.23 × 10(-3) mm(2) /s; D:1.12 ± 0.35 × 10(-3) mm(2) /s; ve :0.27 ± 0.13; K(trans) :0.24 ± 0.09 min(-1) ; kep :0.90 ± 0.45 min(-1) ) and SCC (1.13± 0.28 × 10(-3) mm(2) /s; 1.02 ± 0.32 10(-3) mm(2) /s; 0.32 ± 0.14; 0.26 ± 0.08 min(-1) ; 0.90 ± 0.48 min(-1) ) had significantly lower ADC, D, ve and larger K(trans) , kep than benignity (1.37 ...Continue Reading

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Citations

Jun 15, 2016·Journal of Magnetic Resonance Imaging : JMRI·Xiao-Quan XuFei-Yun Wu
Aug 20, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Ahmed Abdel Khalek Abdel Razek, Germeen Albair Ashmalla
May 2, 2018·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Gao MaFei-Yun Wu
Dec 24, 2018·Journal of Magnetic Resonance Imaging : JMRI·Chi Wan KooTobias Peikert
Feb 6, 2017·Journal of Magnetic Resonance Imaging : JMRI·Vera C KeilDariusch R Hadizadeh
Apr 10, 2020·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Neeraj KumarNavneet Sharma

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