Comparison of investigator-delineated gross tumor volumes and quality assurance in pancreatic cancer: Analysis of the pretrial benchmark case for the SCALOP trial

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Emmanouil FokasSomnath Mukherjee

Abstract

To evaluate the variation in investigator-delineated volumes and assess plans from the radiotherapy trial quality assurance (RTTQA) program of SCALOP, a phase II trial in locally advanced pancreatic cancer. Participating investigators (n=25) outlined a pre-trial benchmark case as per RT protocol, and the accuracy of investigators' GTV (iGTV) and PTV (iPTV) was evaluated, against the trials team-defined gold standard GTV (gsGTV) and PTV (gsPTV), using both qualitative and geometric analyses. The median Jaccard Conformity Index (JCI) and Geographical Miss Index (GMI) were calculated. Participating RT centers also submitted a radiotherapy plan for this benchmark case, which was centrally reviewed against protocol-defined constraints. Twenty-five investigator-defined contours were evaluated. The median JCI and GMI of iGTVs were 0.57 (IQR: 0.51-0.65) and 0.26 (IQR: 0.15-0.40). For iPTVs, these were 0.75 (IQR: 0.71-0.79) and 0.14 (IQR: 0.11-0.22) respectively. Qualitative analysis showed largest variation at the tumor edges and failure to recognize a peri-pancreatic lymph node. There were no major protocol deviations in RT planning, but three minor PTV coverage deviations were identified. . SCALOP demonstrated considerable variation ...Continue Reading

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Citations

Feb 22, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michael Baumann, Jens Overgaard
Mar 22, 2016·Expert Review of Anticancer Therapy·Sten MyrehaugJoseph M Herman
Apr 24, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Emily ChanAnuradha Bapsi Chakravarthy
Aug 9, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Emmanouil FokasSomnath Mukherjee
Oct 27, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Daniel L P HolyoakeMaria A Hawkins
Apr 5, 2017·Acta Oncologica·Oliver J Gurney-ChampionArjan Bel
Jun 14, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Eva VersteijneGeertjan van Tienhoven
Aug 31, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Thomas B BrunnerFalk Roeder
May 14, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michael V ShererErin F Gillespie

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