PMID: 9179705Jun 1, 1997Paper

Comparison of iodinated contrast media-induced renal vasoconstriction in human, rabbit, dog, and pig arteries

Investigative Radiology
D RauchP O Madsen

Abstract

Contrast media (CM)-induced renal vasoconstriction is an important factor in the pathogenesis of CM-induced nephrotoxicity. The effects of ionic, high-osmolar CM sodium/meglumine diatrizoate and nonionic, low-osmolar CM iohexol and iopamidol were studied in rabbit, dog, and pig renal arteries and compared with human tissue in an organ bath. Isometric contractions were induced by increasing concentrations of CM and high-osmolar glucose solution. Contrast media and glucose elicited contractions in human renal arteries of 32% (diatrizoate), 20% (iohexol), 30% (iopamidol), and 22% (glucose). Rabbit and dog renal arteries demonstrated contractions of 30% and 46% (diatrizoate), 15% and 23% (iohexol), 15% and 26% (iopamidol), and 11% and 40% (glucose), respectively, of the control. There was a vasorelaxing effect of all CM tested on pig renal artery. Responses in rabbit and dog renal arteries were similar to those in human renal arteries and could serve as models for investigating CM-induced renal vasoconstriction.

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Citations

Feb 6, 1999·European Journal of Radiology·S K MorcosJ O Karlsson
Oct 19, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Junji Narioka, Yuichi Ohashi
Nov 27, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marcus TreitlJohannes Rieger
Feb 26, 2011·Clinical and Experimental Pharmacology & Physiology·Mauricio M Sendeski
May 31, 2012·Clinical and Experimental Pharmacology & Physiology·Adriano CaixetaGiora Weisz
Sep 13, 2011·Research in Veterinary Science·Miki NishidaMegumi Fujiwara
Nov 11, 1998·Academic Radiology·P DrescherP O Madsen
Mar 23, 2005·Critical Care Clinics·Peter A McCullough, Sandeep S Soman
Sep 5, 2006·The American Journal of Cardiology·James TumlinUNKNOWN CIN Consensus Working Panel
Apr 22, 2015·BioMed Research International·Wen-Bo ChenShui-Xing Zhang
Aug 25, 2016·Journal of Veterinary Emergency and Critical Care·Joana B GoicMatthew W Beal
Nov 30, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Roberto SpinaKrishna Kathir
Nov 3, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Tereza PucelikovaRoxana Mehran
Dec 16, 1998·Investigative Radiology·P DrescherP O Madsen
Feb 9, 2017·Clinical and Experimental Emergency Medicine·Deborah B DiercksMark E Sutter

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