PMID: 8946341Nov 6, 1996Paper

Comparison of isoproterenol with BRL37344 in activation of beta 3-adrenoceptors to inhibit the uptake of [14C]deoxy-D-glucose and translocation of glucose transporter (GLUT4) to membrane fraction in rat adipocytes

Journal of the Autonomic Nervous System
C J ChangJ T Cheng

Abstract

In an attempt to understand the role of beta 3-adrenoceptors in the regulation of glucose uptake, the effect of isoproterenol was compared with BRL37344 in isolated white adipocytes of the rat using [14C]deoxy-D-glucose as an indicator. In the presence of BRL37344, the specific agonist of beta 3-adrenoceptors, spontaneous uptake of [14C]deoxy-D-glucose (glucose uptake) into adipocytes was markedly attenuated. Similar concentration-dependent inhibition of glucose uptake was also observed in the samples treated with isoproterenol, an agonist for all kinds of beta-adrenoceptors. Action of BRL37344 was blocked by propranolol at concentrations sufficient to abolish the activity of isoproterenol. Pindolol reversed BRL37344-induced inhibition more effectively than propranolol. Moreover, unlike the action of isoproterenol, BRL37344 did not modify the insulin-stimulated glucose uptake. Translocation of glucose transporter (GLUT4) from cytosol to membrane stimulated with insulin was reduced by isoproterenol but not by BRL37344. Combination with the findings that isoproterenol prolonged the time for insulin to reach maximum stimulation of glucose uptake, leads to the conclusion that delay of insulin action by isoproterenol can be consider...Continue Reading

References

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Citations

Apr 1, 2000·Journal of the Autonomic Nervous System·T C ChiJ T Cheng
Oct 12, 2001·Autonomic Neuroscience : Basic & Clinical·J T ChengI M Liu
Jan 23, 1999·Journal of the Autonomic Nervous System·T L LeeJ T Cheng
Dec 9, 2000·Autonomic Neuroscience : Basic & Clinical·J T ChengP C Chen
Feb 22, 2000·British Journal of Pharmacology·I M LiuJ T Cheng
Aug 4, 2009·Journal of Food Science·Fang-Chi ChengJames Swi-Bea Wu

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