Comparison of ivabradine versus metoprolol in early phases of reperfused anterior myocardial infarction with impaired left ventricular function: preliminary findings

Journal of Cardiac Failure
Sergio FasulloPietro Di Pasquale

Abstract

beta-blockers in ST-segment elevation myocardial infarction (STEMI) are indicated for patients without a contraindication, particularly in patients with high heart rates (HR) or blood pressures. Epidemiological studies have shown that elevated HR represents a risk factor for cardiovascular morbidity. The study investigates the feasibility, tolerability, and the effects after 30 days of follow-up of ivabradine (IVA) versus metoprolol (METO) in early phases of anterior STEMI reperfused by percutaneous coronary intervention (PCI). Patients with a first anterior STEMI, Killip class I-II, an acceptable echocardiographic window, and admitted within 4hours of the onset of symptoms, with an ejection fraction <50%. METO or IVA, 12hours after PCI (double blind), were administered twice per day. Blood pressure (BP), heart rate (HR), electrocardiogram (ECG), and laboratory parameters were monitored during the study. At entry, day 10, day 30, and day 60, by echocardiography, the ESV, EDV, E/A ratio, E wave deceleration time, isovolumetric relaxation time were measured. A total of 155 (50 females, 105 males) patients were randomized in 2 groups: a group received METO (76 patients) 12hours after PCI and a group received IVA (79 patients) 12ho...Continue Reading

Associated Clinical Trials

Aug 10, 2010·Giuseppe M.C. Rosano, Giuseppe M.C. Rosano

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Citations

Apr 27, 2010·Advances in Therapy·Graziano Riccioni
Nov 26, 2010·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Neeraj Parakh, Balram Bhargava
Jan 24, 2014·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Luis SargentoRoberto Palma dos Reis
Sep 14, 2012·Heart Failure Reviews·Maya Guglin
May 16, 2014·Cardiovascular Therapeutics·Ivano BonadeiMarco Metra
Jan 25, 2011·Expert Opinion on Pharmacotherapy·Graziano Riccioni
Aug 24, 2013·International Journal of Cardiology·Yang Yang, Dao-Quan Peng
May 20, 2014·Journal of Molecular and Cellular Cardiology·Bertrand Rozec
Jan 21, 2014·Archives of Cardiovascular Diseases·Edouard GerbaudPierre Coste
Nov 20, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Graziano Riccioni
Nov 26, 2019·Anesthesiology·Alexandre BedetArmand Mekontso Dessap
Jan 16, 2020·Anesthesiology·Alexandre BedetArmand Mekontso Dessap
Dec 29, 2020·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Yan XuQiang Liu
Mar 20, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mariusz MarciszekMichał Mączewski

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