Comparison of koala LPCoLN and human strains of Chlamydia pneumoniae highlights extended genetic diversity in the species.

BMC Genomics
C MitchellPeter Timms

Abstract

Chlamydia pneumoniae is a widespread pathogen causing upper and lower respiratory tract infections in addition to a range of other diseases in humans and animals. Previous whole genome analyses have focused on four essentially clonal (> 99% identity) C. pneumoniae human genomes (AR39, CWL029, J138 and TW183), providing relatively little insight into strain diversity and evolution of this species. We performed individual gene-by-gene comparisons of the recently sequenced C. pneumoniae koala genome and four C. pneumoniae human genomes to identify species-specific genes, and more importantly, to gain an insight into the genetic diversity and evolution of the species. We selected genes dispersed throughout the chromosome, representing genes that were specific to C. pneumoniae, genes with a demonstrated role in chlamydial biology and/or pathogenicity (n = 49), genes encoding nucleotide salvage or amino acid biosynthesis proteins (n = 6), and extrachromosomal elements (9 plasmid and 2 bacteriophage genes). We have identified strain-specific differences and targets for detection of C. pneumoniae isolates from both human and animal origin. Such characterisation is necessary for an improved understanding of disease transmission and inte...Continue Reading

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Citations

Dec 12, 2012·Trends in Microbiology·Eileen RoulisPeter Timms
Feb 11, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Alexandra Nunes, João P Gomes
Apr 19, 2015·BMC Genomics·Thomas WeinmaierJan Rupp
Jun 22, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·María C FrutosCecilia G Cuffini
Jan 10, 2018·Veterinary Pathology·Nicole BorelAndreas Pospischil
May 6, 2015·Infection and Immunity·Krithika RajaramDavid E Nelson
Oct 12, 2018·MSphere·Kensuke ShimaJan Rupp
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Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Corinna BraunKatja Mölleken
Aug 12, 2014·BMC Genomics·Nathan L BachmannAdam Polkinghorne

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Datasets Mentioned

BETA
AE002161
CWL029
AE001363
AE009440
BA000008
CP001713

Software Mentioned

BioEdit Sequence Alignment Editor
ClustalW2
tblastn
Clustal W
Excel
tblastx
BLAST

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