Comparison of laboratory tests used for identification of the lupus anticoagulant

American Journal of Hematology
S C LoB G Firkin

Abstract

A comparison of the sensitivities of the ten most commonly used tests for the identification of the lupus anticoagulant (LA) and the lupus cofactor phenomenon was undertaken on 18 patients. All investigations, except the cardiolipin-antibody ELISA assay, were carried out using patient's plasma alone followed by a 1:1 mix with control plasma. Dilution studies (1:3, 1:6, 1:9--patient:control) were also carried out. The kaolin clotting time (KCT) was the only test positive in all patients at all dilutions, while the dilute activated partial thromboplastin time with kaolin (Dil-APTT) registered 17 of 18 positive at all dilutions. Both the dilute Russell viper venom time (Dil-RVVT) and the tissue thromboplastin inhibition time (TTI) (1/500 thromboplastin) identified the LA in 17 of 18 patients on initial testing but were less sensitive in the dilution studies. The KCT is not a suitable test for routine laboratory use, as it requires an individual filtration step. Therefore a combination of either the Dil-APTT or Dil-RVVT together with the TTI (1/500 dilution thromboplastin) is recommended for routine LA screening, as all patients with LA in this study were identified using these easily automated tests. The lupus cofactor phenomenon ...Continue Reading

References

Nov 1, 1976·Arthritis and Rheumatism·M BoxerA Carvalho
Feb 1, 1986·Annals of Internal Medicine·A J CohenC M Kessler
Jan 1, 1987·The American Journal of the Medical Sciences·M AverbuchY Levo
Feb 1, 1985·American Journal of Clinical Pathology·T Exner
Jul 1, 1985·American Journal of Hematology·D A GastineauE J Bowie
Oct 1, 1974·Annals of Internal Medicine·M G ReganS Karpatkin
Jan 1, 1972·The Medical Clinics of North America·D Green
Jan 1, 1974·Haemostasis·K Lechner
Oct 8, 1983·British Medical Journal·R A AshersonG R Hughes
Jan 1, 1984·Stroke; a Journal of Cerebral Circulation·R G HartV Bril
Apr 1, 1984·British Journal of Obstetrics and Gynaecology·W F LubbeG C Liggins
Sep 1, 1982·American Journal of Hematology·R T Canoso, H S Sise
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Feb 1, 1980·Annals of Internal Medicine·J R MuehS I Rapaport
Aug 1, 1980·Annals of the Rheumatic Diseases·D D Gladman, M B Urowitz
Nov 1, 1955·American Journal of Clinical Pathology·C A OWENF D MANN
Dec 1, 1955·The Journal of Clinical Investigation·S L LEE, M SANDERS

❮ Previous
Next ❯

Citations

Jan 1, 1992·International Journal of Clinical & Laboratory Research·C LegnaniS Coccheri
Feb 1, 1994·Pediatric Neurology·J C OlsonB M Coull
Dec 10, 1999·Thrombosis Research·R LuddingtonT Baglin
Mar 1, 1992·British Journal of Haematology·J ArnoutJ Vermylen
Jun 1, 1990·American Journal of Reproductive Immunology : AJRI·M TaylorR R Buchanan
Mar 1, 1990·Journal of Clinical Pathology·M Magrath
Jan 19, 2011·Blood Reviews·Rolf T Urbanus, Philip G de Groot
Oct 28, 2004·Thrombosis Research·Ronald H W M Derksen, Philip G de Groot
Oct 1, 1989·British Journal of Haematology·D A Triplett, J Brandt
Feb 1, 1997·Journal of the American Academy of Dermatology·G T Nahass
Jan 29, 1999·Hematology/oncology Clinics of North America·P Thiagarajan, S S Shapiro
Jul 18, 2002·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Rolandas GerbutaviciusRasa Griniute
May 7, 2002·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Rolandas GerbutaviciusRasa Griniute
Nov 1, 1989·American Journal of Hematology·M H RosoveA Runge
Oct 1, 1990·Seminars in Arthritis and Rheumatism·L R SammaritanoM D Lockshin
Oct 1, 1989·La Ricerca in Clinica E in Laboratorio·D A Triplett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.