Comparison of laparoscopic and abdominal radical hysterectomy for early stage cervical cancer: oncologic outcomes based on tumor diameter.

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Junshen HeChunlin Chen

Abstract

Early stage cervical cancer is prevalent in China and remains a major public health burden in developing countries. We aimed to determine the long term oncologic outcomes between laparoscopic and abdominal radical hysterectomy in patients with early cervical cancer. We conducted a multicenter, retrospective, case-control study of 37 hospitals. All consecutive early stage cervical cancer patients with International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IA1 with lymphovascular space invasion to IB1, who underwent laparoscopic or abdominal radical hysterectomy between January 2004 and December 2016, were included. We compared the disease free survival and overall survival of the two approaches in 1:1 case-control matched settings based on prognosis related factors. We selected 8470 of 46 313 patients. After matching (n=1601/1601), we found that laparoscopic surgery was associated with significantly worse 5 year disease free survival (89.5% vs 93.1%, p=0.001; hazard ratio (HR) 1.60, p=0.001), but not 5 year overall survival (94.3% vs 96.0%, HR=1.48, p=0.058). In the subgroup analysis, in patients with a tumor diameter <2 cm (n=739/739), both 5 year disease free survival and overall survival were similar between ...Continue Reading

References

Mar 23, 1992·European Journal of Obstetrics, Gynecology, and Reproductive Biology
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Apr 25, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·David CibulaMaria Rosaria Raspollini
Oct 12, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Neerja BhatlaRengaswamy Sankaranarayanan
Nov 1, 2018·The New England Journal of Medicine·Alexander MelamedJ Alejandro Rauh-Hain
Nov 1, 2018·The New England Journal of Medicine·Pedro T RamirezAndreas Obermair
Jan 15, 2019·Lancet·Paul A CohenLynette Denny
Mar 1, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·David CibulaMaria Rosaria Raspollini
Jul 10, 2019·American Journal of Obstetrics and Gynecology·Maria C CusimanoSarah E Ferguson
Feb 8, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shitanshu UppalStephen L Rose

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Citations

Jan 29, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Juliana RodriguezRene Pareja
Jul 23, 2021·Archives of Gynecology and Obstetrics·Rüdiger KlapdorPeter Hillemanns
Jun 25, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Yuanyi YuShequn Gu

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