Comparison of late results of basic transsternal and extended transsternal thymectomies in the treatment of myasthenia gravis

The Annals of Thoracic Surgery
Marcin ZielińskiJerzy Soja

Abstract

The influence of the technique of thymectomy on late results in the treatment of myasthenia gravis remains controversial. Results of 60 basic transsternal thymectomies and 58 extended transsternal thymectomies were compared. Both positive results (complete remissions or improvement) and negative results (no improvement, deterioration, or death from myasthenia) were analyzed. There were no differences between both groups according to patient's characteristics and postoperative complications rate. Ectopic foci of the thymic tissue were discovered in the fat of the neck and the mediastinum in 56.9% of patients from the extended thymectomy group. The foci occurred in all areas of dissection of the neck and the mediastinum. Complete remission rates in the basic thymectomy group were 8.3%, 11.7%, 15.0%, 16.7%, 20.0%, and 21.7% after 1, 2, 3, 4, 5, and 6 years of follow-up, respectively, and 29.3%, 37.9%, 41.4%. and 46.6% after 1, 2, 3, and 4 years, respectively, in the extended thymectomy group. The differences between both groups after 1, 2, 3, and 4 years were statistically significant (p = 0.0093, p = 0.0013, p = 0.0018, and p = 0.0007, respectively). Negative results were noted in 23.3% of patients in the basic thymectomy group a...Continue Reading

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Citations

Sep 2, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·José M PonsetiManuel Armengol
Mar 1, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Wiesława Klimek-PiotrowskaJuliusz Pankowski
Oct 1, 2007·Journal of Minimal Access Surgery·Marcin ZielińskiArtur Szlubowski
Jul 24, 2013·Age·Rita RezzaniLuigi Fabrizio Rodella
Jan 1, 2005·Multimedia Manual of Cardiothoracic Surgery : MMCTS·Marcin ZielinskiTomasz Nabialek
Apr 30, 2014·European Journal of Immunology·Christa SmolarchukColin C Anderson
Jul 28, 2004·The Annals of Thoracic Surgery·Marcin ZielińskiJerzy Soja
Mar 27, 2010·The Annals of Thoracic Surgery·Seth D Goldstein, Stephen C Yang
Nov 26, 2011·The Annals of Thoracic Surgery·Zhenguo LiuChao Cheng
Jun 24, 2008·Annals of the New York Academy of Sciences·Joshua R Sonett, Alfred Jaretzki
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·James DooleyAndrew G Farr
Aug 31, 2018·Der Pathologe·A MarxC-A Weis
Oct 20, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Feng LiJens-C Rückert
Jul 15, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Kai ZhuHuiyu Feng
Nov 26, 2020·Interactive Cardiovascular and Thoracic Surgery·Mitsuteru YoshidaAkira Tangoku
Aug 19, 2021·ANZ Journal of Surgery·Do Kyun KangYoun-Ho Hwang

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