Abstract
Lawsonia inermis L. (Lythraceae) is cultivated in many countries, including Japan, China, India and Egypt. Its leaves are well known as hair dye and exhibit antibacterial, anticancer, antifungal and anticonvulsant activities. However, there are few reports on its branches. 2-Hydroxy-1,4-naphthoquinone (lawsone) is a characteristic compound in its leaves. However, it remains to be clarified whether lawsone is present in other plant parts or not. In this study, we measured lawsone contents in the extracts of L. inermis flowers, leaves and branches by HPLC with tandem mass spectrometry. The extracts of L. inermis flowers, leaves and branches contained 116.9, 486.2 and 5.4 μg/g lawsone, respectively. Lawsone content was much lower in branches than the other plant parts. Next, in order to identify the biological constituents in the branches, we isolated nine known compounds and examined their effects on neurite outgrowth in PC12 cells. Among the constituents isolated, 2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propane-1,3-diol (1) and quercetin 7-O-β-D-glucopyranoside (8) showed accelerative effects on neurite outgrowth in PC12 cells.
References
Jan 15, 1978·Experientia·R D TripathiS N Dixit
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L A Greene, A S Tischler
Dec 12, 2001·Phytochemistry·B S Siddiqui, M N Kardar
Dec 17, 2002·Phytochemistry·Kohei KazumaMasahiko Suzuki
Aug 7, 2007·Journal of Pharmacological Sciences·Toru OdaAkinori Akaike
Jul 4, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Simona De MarinoMaria Iorizzi
Sep 17, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lin-chun FuXiao-ling Cai
Dec 2, 2009·Planta medica·Tai-Hung ChenTing-Ting Jong
Jul 17, 2010·Bioorganic & Medicinal Chemistry Letters·Nguyen Xuan CuongYoung Ho Kim
Oct 12, 2010·Cytotechnology·Myoung Hoon JeongHyeon Yong Lee
Nov 3, 2010·Journal of Agricultural and Food Chemistry·Liya Li, Navindra P Seeram
Jan 29, 2013·Phytochemistry·Jing-Ru LiouYang-Chang Wu
May 20, 2015·Bioorganic & Medicinal Chemistry Letters·Souichi NakashimaHisashi Matsuda
Mar 5, 2016·Journal of Natural Medicines·Yoshimi OdaHisashi Matsuda
Oct 1, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chang-Syun YangYueh-Hsiung Kuo
Nov 9, 2017·Natural Product Research·Xiao-Xiao HuangXiao-Bo Wang
Citations
Apr 14, 2019·International Journal of Molecular Sciences·Małgorzata RudnickaWaldemar Karcz
Aug 28, 2020·Cancer Investigation·Sharmeen IshteyaqueMadhav Nilakanth Mugale
Nov 11, 2019·Journal of Natural Medicines·Mamiko YanoHisashi Matsuda
Jun 22, 2021·Cutaneous and Ocular Toxicology·Razieh MohajeraniMinoo Afshar