Comparison of LDL fatty acid and carotenoid concentrations and oxidative resistance of LDL in volunteers from countries with different rates of cardiovascular disease

The British Journal of Nutrition
Anthony J A WrightD I Thurnham

Abstract

Within Europe there are differences in cardiovascular disease (CVD) risk between countries and this might be related to dietary habits. Oxidative modification of LDL is suggested to increase the risk of CVD and both the fatty acid and antioxidant content of LDL can affect its oxidation. In the present study, concentration of LDL fatty acid and antioxidant micronutrients (tocopherols and carotenoids) and ex vivo oxidative resistance of LDL (lag phase) was compared in volunteers from five countries with different fruit and vegetable intakes and reported rates of CVD. Eighty volunteers (forty males, forty females per centre), age range 25-45 years, were recruited from France, Northern Ireland, UK, Republic of Ireland, The Netherlands, and Spain, and their LDL composition and lag phase were measured. There were some differences in LDL carotenoid and alpha-tocopherol concentrations between countries. alpha-Tocopherol was low and beta- + gamma-tocopherol were high (P<0.001) in the Dutch subjects. Beta-Carotene concentrations were significantly different between the French and Spanish volunteers, with French showing the highest and Spanish the lowest concentration. LDL lycopene was not different between centres in contrast to lutein, ...Continue Reading

References

Mar 1, 1992·The American Journal of Clinical Nutrition·L R CantilenaD W Nierenberg
Dec 1, 1991·The Journal of Clinical Investigation·J L Witztum, D Steinberg
Dec 19, 1990·JAMA : the Journal of the American Medical Association·D Steinberg, J L Witztum
Dec 1, 1990·Pathologie-biologie·W Hornebeck
Jan 1, 1989·Annals of the New York Academy of Sciences·M G Traber, H J Kayden
Jan 1, 1989·Free Radical Research Communications·H EsterbauerM Rotheneder
Oct 1, 1993·The American Journal of Clinical Nutrition·M AbbeyP A Baghurst
May 1, 1996·The American Journal of Clinical Nutrition·A M LouherantaJ T Salonen
Jul 1, 1997·Free Radical Research·L P Van de VijverH M Princen
Nov 5, 1997·European Journal of Clinical Nutrition·I HiningerA M Roussel
Sep 12, 1998·The American Journal of Clinical Nutrition·D I ThurnhamM Chopra
Apr 28, 2000·European Journal of Nutrition·I Elmadfa, E Park

❮ Previous
Next ❯

Citations

Nov 29, 2005·Molecular Aspects of Medicine·Norman I Krinsky, Elizabeth J Johnson
Feb 13, 2015·Critical Reviews in Food Science and Nutrition·Lars MüllerVolker Böhm
May 29, 2004·Current Opinion in Lipidology·Aaron T Lada, Lawrence L Rudel
Jan 11, 2005·Journal of the American College of Nutrition·Judy D Ribaya-Mercado, Jeffrey B Blumberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.